Antimicrobial Therapy in Veterinary Medicine, 6th Edition

Patricia M. Dowling (Editor), John F. Prescott (Editor), Keith E. Baptiste (Editor) 

ISBN: 9781119654599

December 2024

Wiley-Blackwell

880 pages

Description

Provides a comprehensive, fully updated reference book to the general principles and clinical applications of antimicrobials in veterinary medicine

The sixth edition of Antimicrobial Therapy in Veterinary Medicine has been updated to reflect advances in the field, including new international contributors and a broader global outlook. It includes extensive knowledge of both general principles of mechanisms of antimicrobial drug action including specific classes of antimicrobial agents, as well as chapters dedicated to antimicrobial drug use in a wide range of animal species. As antimicrobial resistance increases as a major global issue in both human and animal health, this book’s renewed focus on antimicrobial stewardship in companion animals, in food animals, and on global aspects keeps it at the forefront of this vital field.

The Sixth Edition of this classic text offers:

• Updates to every chapter, reflecting new developments and research, with a complete examination of the issues associated with antimicrobial resistance

• A comprehensive reference for all aspects of antimicrobial use in veterinary medicine, encompassing theory and practice

• A global perspective on antimicrobial therapy, with more international content than previous editions

• A stronger emphasis on antimicrobial stewardship, with practical guidance for prescribing antimicrobial drugs

• A companion website with tables and figures from the book available for download

Antimicrobial Therapy in Veterinary Medicine is an essential and accessible resource for veterinarians, veterinary students, scientists, and professionals in veterinary medicine and antimicrobial research and stewardship.

Table of Contents

Contributors ix

Preface xiii

Acknowledgments xv

Important Notice xvii

List of Abbreviations xix

Section I General Principles of Antimicrobial Therapy 1

1 Antimicrobial Drug Action and Interaction: An Introduction 3

2 Antimicrobial Susceptibility Testing Methods and Interpretation of Results 13

3 Antimicrobial Resistance and Its Epidemiology 29

4 Pharmacokinetics of Antimicrobials 51

5 Pharmacodynamics of Antimicrobials 81

6 Principles of Antimicrobial Drug Selection and Use 109

Section II Classes of Antimicrobial Agents 119

7 Beta-lactam Antibiotics: Penam Penicillins 121

8 Beta-lactam Antibiotics: Cephalosporins 143

9 Other Beta-lactam Antibiotics: Beta-lactamase Inhibitors, Carbapenems, and Monobactams 169

10 Peptide Antibiotics: Polymyxins, Glycopeptides, Bacitracin, and Fosfomycin 187

11 Lincosamides, Pleuromutilins, and Streptogramins 203

12 Macrolides, Azalides, and Ketolides 223

13 Aminoglycosides and Aminocyclitols 249

14 Tetracyclines 273

15 Chloramphenicol, Thiamphenicol, and Florfenicol 291

16 Sulfonamides, Diaminopyrimidines, and Their Combinations 305

17 Fluoroquinolones 325

18 Miscellaneous Antimicrobials: Ionophores, Nitrofurans, Nitroimidazoles, Rifamycins, and Others 345

19 Antifungal Chemotherapy 371

Section III Antimicrobial Stewardship 401

20 General Concepts in Antimicrobial Stewardship 403

21 Global Aspects of One Health Antimicrobial Stewardship 425

22 Antimicrobial Stewardship in Companion Animals 445

23 Antimicrobial Stewardship in Food-producing Animals 459

24 Antimicrobial Prophylaxis, Metaphylaxis, and the Treatment of Immunocompromised Patients 487

25 Regulation of Antimicrobial Use in Animals 513

26 Antimicrobial Drug Residues in Foods of Animal Origin 527

Section IV Antimicrobial Therapy in Selected Animal Species 545

27 Antimicrobial Drug Use in Horses 547

28 Antimicrobial Therapy in Dogs and Cats 577

29 Antimicrobial Therapy in Beef Cattle 611

30 Antimicrobial Therapy in Dairy Cattle 635

31 Antimicrobial Therapy in Sheep and Goats 655

32 Antimicrobial Therapy in New World Camelids 671

33 Antimicrobial Therapy in Swine 685

34 Antimicrobial Therapy in Poultry 697

35 Antimicrobial Therapy in Companion Birds 721

36 Antimicrobial Therapy in Rabbits, Rodents, and Ferrets 735

37 Antimicrobial Therapy in Reptiles 767

38 Antimicrobial Therapy in Zoo and Wildlife Species 791

39 Antimicrobial Therapy in Aquaculture 803

40 Antimicrobial Therapy in Honey Bees 819

Index 831

About the Author

Patricia M. Dowling, DVM, MSc, DACVIM, DACVCP, is Professor of Veterinary Clinical Pharmacology at the Western College of Veterinary Medicine, University of Saskatchewan in Saskatoon, Saskatchewan, Canada.

John F. Prescott, MA, VetMB, PhD, FCAHS, is University Professor Emeritus at the Ontario Veterinary College, University of Guelph in Guelph, Ontario, Canada.

Keith E. Baptiste, BVMS, MSc, PhD, MRCVS, DACVIM, DECEIM, is Senior Veterinary Consultant in the Department of Veterinary Medicine at Danish Medicines Agency in Copenhagen, Denmark.