Key Features

Authored by world experts in heart development and disease

New research on epigenetic modifiers in cardiac development

Comprehensive coverage of stem cells and prospects for cardiac regeneration

Up-to-date research on transcriptional and proteomic circuits in cardiac disease

Full-color, detailed illustrations

Contents

Volume 1

1.1 Evolutionary Origins of Hearts

1.2 Development and Aging of the Drosophila Heart

1.3 Cardiac Development in the Frog

1.4 Cardiac Development in the Zebrafish

1.5 An Overview of Avian Heart Structure and Development

2.1 The Specification of Myocardial Progenitor Cells in the Ciona Tadpole

2.2 The Secondary Heart Field

2.3 Patterning and Development of the Conduction system of the Heart

3.1 The Behaviour of Cells that Form the Myocardial Compartments of the Heart
3.2 The Ballooning Model for Formation of Cardiac Chambers

3.3 Retinoids and Heart Development

3.4 A System for Describing Congenital Cardiac Malformations and Correlating Them With Abnormal Cardiac Development

4.1 Cardiac Left-Right Asymmetry

4.2 Molecular Mechanisms of Left/Right Development

4.3 Pitx2 in Cardiac Left Right Asymmetry and Human Disease

5.1 Epicardial Lineage: Origins and Fates

5.2 The Epicardial Signaling Center in Development and Disease

6.1 Molecular Regulation of Cushion Morphogenesis

6.2 Signalling Pathways in Valve Formation: Origins of Congenital Defects

7.1 Role of Cardiac Neural Crest Cells in Morphogenesis of the Heart and Great Vessels

7.2 Role of Cardiac Neural Crest in the Development of the Caudal Pharyngeal Arches, the Cardiac Outflow and Disease

8.1 Origin of the Vertebrate Endothelial Cell Lineage: Ontogeny and Phylogeny

8.2 Vascular Development

8.3 Arterio-Venous Patterning in the Vascular System

8.4 Lymphatic Vascular Development

Volume 2

1.1 NK-2 Class Homeodomain Proteins: Conserved Regulators of Cardiogenesis

1.2 GATA4 in Heart Development and Disease

1.3 Serum Response Factor and Cofactors, Roles in Cardiac Development

1.4 T-box Factors

1.5 Myocyte Enhancer Factor 2 Transcription Factors in Heart Development and Disease

2.1 Chromatin Modification and Remodeling in Heart Development

2.2 Histone Deacetylases in Cardiovascular Development and Disease

2.3 MicroRNA Regulation of Cardiac Development and Disease

3.1 Genomic Analysis in the Developing and Diseased Heart

3.2 Exploring Congenital Cardiovascular Anomalies with ENU Mutagenesis

3.3 Imaging Cardiac Developmental Malformations in the Mouse Embryo

3.4 Proteomic Strategies for Cardiac Transcription Factor Identification

3.5 Proteomic Analysis of MEF2 Post-Translational Regulation in the Heart

4.1 The Evolution of Regeneration

4.2 Cardiac Regeneration in the Zebrafish Model System

5.1 Detection and Identification of Tissue Stem Cells: Tracking an Elusive Prey

5.2 Human Cardiomyocytes from Embryonic Stem Cells: Windows to Human Biology and Elements for Regeneration

6.1 Adult Stem Cell-Based Therapy for the Heart

6.2 Cell Therapy for Recapitulation of Vascular Network Formation and Functional Heart Muscle Recovery After Myocardial Ischaemia

6.3 Cardiac Regeneration and Ageing

6.4 Genetic Enhancement of Cardiac Regeneration

Author Information

Edited by Nadia Rosenthal, European Molecular Biology Laboratory, Monterotondo (Rome), Italy and Richard P. Harvey, Victor Chang Cardiac Research Institute, Sydney, Australia