Description

The new 4^th edition of Histopathology of Preclinical Toxicity Studies is now completely in full color and continues to describe the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. Organized according to organ systems, this revision features a thoroughly updated bibliography and discusses new drug-induced pathologies and applicable species comparisons to aid in the preclinical safety assessment of new medicines. This updated reference is essential for those involved in drug safety evaluation, including pathologists, toxicologists and pharmacologists working in corporate, government, academic and research settings.



Table of Contents

Chapter 1: Introduction
Chapter 2: Integumentary System
- Skin and subcutaneous tissue
Chapter 3: Mammary Gland
Chapter 4: Haemopoietic and Lymphatic Systems
- Blood/bone marrow
- Lymphoid system
- Lymph nodes
- Spleen
- Thymus
- Lymphoreticular neoplasms
Chapter 5: Musculoskeletal System
- Bone
- Joints
- Skeletal muscle
Chapter 6: Respiratory Tract
- Nose, nasal sinuses, nasopharynx and pharynx
- Larynx and trachea
- Bronchi and lungs
Chapter 7: Cardiovascular System
- Heart and pericardium
- Systemic blood vessels
- Pulmonary blood vessels
Chapter 8: Gastrointestinal tract
- Forestomach
- Stomach (glandular)
- Small intestine
- Large intestine
Chapter 9: Liver and Pancreas
- Liver
- Bile ducts, biliary system
- Pancreas
Chapter 10: Urinary System
- Kidney
- Urinary bladder
Chapter 11: Male Genital Tract
- Prostate gland
- Epididymis
- Testis
Chapter 12: Female Genital Tract
- Vagina
- Cervix
- Uterus
- Ovary
Chapter 13: Endocrine System
- Pituitary gland
- Adrenal gland
- Thyroid gland
- Parathyroid gland
Chapter 14: Nervous System and Special Sense Organs
- Brain
- Spinal cord, spinal nerve roots, peripheral nerves
- Eye
- Ear
Subject index