Preface xi

Acknowledgments xiii

About the Companion Website xv

PART I INTRODUCTION 1

1 Pathogenicity and Virulence 3
D. ScottMcVey and Charles Czuprynski

2 Immune Responses to Infectious Agents 7
Laurel J. Gershwin

3 Laboratory Diagnosis 18
D. ScottMcVey

4 Antimicrobial Chemotherapy 26
John F. Prescott

5 Vaccines 45
Ronald D. Schultz and D. ScottMcVey

PART II BACTERIA AND FUNGI 51

6 Family Enterobacteriaceae 53
Rodney Moxley

7 Enterobacteriaceae: Escherichia 62
Rodney Moxley

8 Enterobacteriaceae: Salmonella 75
Rodney Moxley

9 Enterobacteriaceae: Yersinia 85
Rodney Moxley

10 Enterobacteriaceae: Shigella 95
Rodney Moxley

11 Pasteurellaceae: Avibacterium, Bibersteinia, Mannheimia, and Pasteurella 101
Amelia R.Woolums

12 Pasteurellaceae: Actinobacillus 108
Bradley W. Fenwick and Amelia R.Woolums

13 Pasteurellaceae: Haemophilus and Histophilus 115
Amelia R.Woolums

14 Bordetella 120
Bradley W. Fenwick

15 Brucella 127
Steven Olsen and Brian Bellaire

16 Burkholderia mallei and Burkholderia pseudomallei 134
Sanjeev Narayanan

17 Francisella tularensis 139
Peter C. Iwen

18 Moraxella 145
Huchappa Jayappa and D. Scott McVey

19 Pseudomonas 148
Sanjeev Narayanan

20 Taylorella 151
Megan E. Jacob

21 Spiral-Curved Organisms I: Borrelia 155
Rance B. LeFebvre

22 Spiral-Curved Organisms II: Brachyspira (Serpulina) and Lawsonia 158
Jerome C. Nietfeld

23 Spiral-Curved Organisms III: Campylobacter and Arcobacter 167
Jerome C. Nietfeld

24 Spiral-Curved Organisms IV: Helicobacter 175
Megan E. Jacob

25 Spiral-Curved Organisms V: Leptospira 179
Rance B. LeFebvre

26 Staphylococcus 184
Mark S. Smeltzer and Karen E. Beenken

27 Streptococcus and Enterococcus 194
George C. Stewart

28 Arcanobacterium 203
T. G. Nagaraja

29 Bacillus 206
George C. Stewart and BrianM. Thompson

30 Corynebacterium 212
T.G. Nagaraja

31 Erysipelothrix 218
Timothy Frana

32 Listeria 223
Sanjeev Narayanan

33 Rhodococcus 228
Seth P. Harris and Joshua B. Daniels

34 Gram-Negative, Non-spore-Forming Anaerobes 234
T.G. Nagaraja

35 Clostridium 245
John F. Prescott

36 Filamentous Bacteria: Actinomyces, Nocardia, Dermatophilus, and Streptobacillus 263
Megan E. Jacob

37 Mycobacterium 270
Raul G. Barletta and David J. Steffen

38 Chlamydiaceae 279
Roman R. Ganta

39 Mollicutes 283
Erin L. Strait and Melissa L. Madsen

40 Rickettsiaceae and Coxiellaceae: Rickettsia and Coxiella 293
Roman R. Ganta

41 Anaplasmataceae: Ehrlichia and Neorickettsia 297
Roman R. Ganta

42 Anaplasmataceae: Anaplasma 302
Roman R. Ganta

43 Bartonellaceae 306
Bruno B. Chomel and RickieW. Kasten

44 Yeasts—Cryptococcus, Malassezia, and Candida 313
Lisa M. Pohlman and M.M. Chengappa

45 Dermatophytes 321
M.M. Chengappa and LisaM. Pohlman

46 Agents of Subcutaneous Mycoses 326
Lisa M. Pohlman and M.M. Chengappa

47 Agents of Systemic Mycoses 332
M.M. Chengappa and LisaM. Pohlman

PART III VIRUSES 345

48 Pathogenesis of Viral Diseases 347
Melissa Kennedy

49 Parvoviridae and Circoviridae 353
Richard A. Hesse, Benjamin R. Trible, and Raymond R. Rowland

50 Asfarviridae and Iridoviridae 363
Melissa Kennedy

51 Papillomaviridae and Polyomaviridae 366
Melissa Kennedy

52 Adenoviridae 369
Melissa Kennedy and D. Scott McVey

53 Herpesviridae 372
Rebecca P. Wilkes

54 Poxviridae 387
Gustavo A. Delhon

55 Picornaviridae 396
Luis L. Rodriguez and Peter W. Krug

56 Caliciviridae 403
Melissa Kennedy

57 Togaviridae and Flaviviridae 408
Christopher C.L. Chase

58 Orthomyxoviridae 425
WenjunMa

59 Bunyaviridae 433
D. ScottMcVey, Barbara Drolet, and William Wilson

60 Paramyxoviridae, Filoviridae, and Bornaviridae 438
Stefan Niewiesk andMichael Oglesbee

61 Rhabdoviridae 448
Deborah J. Briggs

62 Coronaviridae 456
Udeni B.R. Balasuriya

63 Arteriviridae and Roniviridae 474
Udeni B.R. Balasuriya

64 Reoviridae 491
D. ScottMcVey, William Wilson, and Barbara Drolet

65 Birnaviridae 501
Melissa Kennedy

66 Retroviridae 503
Frederick J. Fuller

67 Transmissible Spongiform Encephalopathies 523
Dongseob Tark and Juergen A. Richt

PART IV CLINICAL APPLICATIONS 533

68 Circulatory System and Lymphoid Tissues 535
Douglas E. Hostetler

69 Digestive System and Associated Organs 544
Douglas E. Hostetler

70 Integumentary System 555
Douglas E. Hostetler

71 Musculoskeletal System 564
Douglas E. Hostetler

72 Nervous System 570
Douglas E. Hostetler

73 Ocular Infections 577
Douglas E. Hostetler

74 Respiratory System 582
Douglas E. Hostetler

75 Urogenital System 591
Douglas E. Hostetler

Index 599