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조직/병리학 > Histology > A Practical Guide to the Histology of the Mouse - [ POD : 해외 주문제작 도서 ]

 
A Practical Guide to the Histology of the Mouse - [ POD : 해외 주문제작 도서 ]
상품명 : A Practical Guide to the Histology of the Mouse - [ POD : 해외 주문제작 도서 ]
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A Practical Guide to the Histology of the Mouse - [ POD : 해외 주문제작 도서 ]

 

POD(Printed On Demand/주문형서적) 상품 안내

 

이 도서는 POD상품입니다.

POD: 품절/절판된 도서를 전자파일로 보유, 주문시 책의 형태로 인쇄/제본한 도서, 오리지날
         도서와 차이가 있을 수 있습니다.


ISBN: 9781119941200
248 pages
February 2014, Wiley-Blackwell


Description
A Practical Guide to the Histology of the Mouse provides a full-colour atlas of mouse histology. Mouse models of disease are used extensively in biomedical research with many hundreds of new models being generated each year. Complete phenotypic analysis of all of these models can benefit from histologic review of the tissues.

This book is aimed at veterinary and medical pathologists who are unfamiliar with mouse tissues and scientists who wish to evaluate their own mouse models. It provides practical guidance on the collection, sampling and analysis of mouse tissue samples in order to maximize the information that can be gained from these tissues. As well as illustrating the normal microscopic anatomy of the mouse, the book also describes and explains the common anatomic variations, artefacts associated with tissue collection and background lesions to help the scientist to distinguish these changes from experimentally- induced lesions.

This will be an essential bench-side companion for researchers and practitioners looking for an accessible and well-illustrated guide to mouse pathology.

  • Written by experienced pathologists and specifically tailored to the needs of scientists and histologists
  • Full colour throughout
  • Provides advice on sampling tissues, necropsy and recording data
  • Includes common anatomic variations, background lesions and artefacts which will help non-experts understand whether histologic variations seen are part of the normal background or related to their experimental manipulation


    Table of Contents
    List of contributors ix
    Foreword xi
    Preface xiii
    About the companion website xv

    Chapter 1 Necropsy of the mouse 1
    Lorna Rasmussen and Elizabeth McInnes

    1.1 Recording of findings 2

    1.2 Bleeding technique 3

    1.3 Perfusion 3

    1.4 External examination 4

    1.5 Weighing of organs 6

    1.6 Positioning of mouse for necropsy and removing the skin 6

    1.7 Opening the abdominal cavity and exposing organs 9

    1.8 Removing the ribcage to expose lungs and heart 17

    1.9 Removing the brain and spinal cord 20

    1.10 Collecting and fixing tissue samples 22

    References 22

    Chapter 2 Practical approaches to reviewing and recording pathology data 25
    Cheryl L. Scudamore

    2.1 Sample selection and trimming patterns 26

    2.2 Controls 28

    2.3 Standardizing terminology 28

    2.4 Microscopic terminology 30

    2.5 Recording pathology data 33

    2.6 Quantitative versus semiquantitative analysis 35

    2.7 Semiquantitative techniques 37

    2.8 Quantitative techniques 38

    References 40

    Chapter 3 Gastrointestinal system 43
    Cheryl L. Scudamore

    3.1 Background and development 43

    3.2 Oral cavity 43

    3.3 Salivary glands 46

    3.4 Stomach and intestines 48

    3.5 Liver 56

    3.6 Pancreas 59

    References 61

    Chapter 4 Cardiovascular system 63
    Cheryl L. Scudamore

    4.1 Background and development 63

    4.2 Sampling techniques and morphometry 63

    4.3 Artefacts 65

    4.4 Anatomy and histology of the heart 67

    4.5 Anatomy and histology of the blood vessels 69

    References 72

    Chapter 5 Urinary system 75
    Elizabeth McInnes

    5.1 Background and development 75

    5.2 Sampling techniques 76

    5.3 Artefacts 76

    5.4 Background lesions 77

    5.5 Anatomy and histology 79

    References 85

    Chapter 6 Reproductive system 87
    Cheryl L. Scudamore

    6.1 Background and development of the male and female reproductive tract 87

    6.2 Female reproductive tract 88

    6.3 Male reproductive tract 97

    References 105

    Chapter 7 Endocrine system 109
    Ian Taylor

    7.1 Introduction 109

    7.2 Adrenals 109

    7.3 Pituitary 114

    7.4 Thyroids and parathyroids 117

    References 121

    Chapter 8 Nervous system 123
    Aude Roulois

    8.1 Introduction 123

    8.2 Necropsy 123

    8.3 Fixation/perfusion 126

    8.4 Trimming 131

    8.5 Special stains and techniques 133

    8.6 Microscopic examination 137

    8.7 Normal histology-juvenile – CNS and PNS 137

    8.8 Artefacts – CNS and PNS 141

    8.9 Pathological changes and background pathology – CNS and PNS 142

    8.10 Acknowledgment 146

    References 146

    Useful website resources 148

    Chapter 9 Lymphoid and haematopoietic system 149
    Ian Taylor

    9.1 Introduction 149

    9.2 Lymph nodes 150

    9.3 Spleen 156

    9.4 MALT (mucosa-associated lymphoid tissue) 160

    9.5 Thymus 161

    9.6 Bone marrow 164

    References 166

    Chapter 10 Integument and adipose tissue 169
    Cheryl L. Scudamore

    10.1 Background and development 169

    10.2 Sampling technique 170

    10.3 Anatomy and histology 171

    References 177

    Chapter 11 The respiratory system 179
    Elizabeth McInnes

    11.1 Background and development 179

    11.2 Embryology 179

    11.3 Anatomy and histology of the respiratory system 180

    11.4 Upper respiratory tract 180

    11.5 Lower respiratory tract 189

    References 193

    Chapter 12 Special senses 195
    Cheryl L. Scudamore

    12.1 Background and development 195

    12.2 Sampling technique for the eye 195

    12.3 Artefacts 197

    12.4 Anatomy and histology of the eye and associated glands 199

    12.5 Background and development of the ear 204

    12.6 Sampling technique for the ear and associated structures 205

    12.7 Anatomy and histology of the ear and associated glands 206

    References 209

    Chapter 13 Musculoskeletal system 211
    Cheryl L. Scudamore

    13.1 Background and development 211

    13.2 Sampling techniques 211

    13.3 Anatomy and histology 212

    References 218

    Index 221

    List of contributors ix

    Foreword xi

    Preface xiii

    About the companion website xv

    Chapter 1 Necropsy of the mouse 1
    Lorna Rasmussen and Elizabeth McInnes

    1.1 Recording of findings 2

    1.2 Bleeding technique 3

    1.3 Perfusion 3

    1.4 External examination 4

    1.5 Weighing of organs 6

    1.6 Positioning of mouse for necropsy and removing the skin 6

    1.7 Opening the abdominal cavity and exposing organs 9

    1.8 Removing the ribcage to expose lungs and heart 17

    1.9 Removing the brain and spinal cord 20

    1.10 Collecting and fixing tissue samples 22

    References 22

    Chapter 2 Practical approaches to reviewing and recording pathology data 25
    Cheryl L. Scudamore

    2.1 Sample selection and trimming patterns 26

    2.2 Controls 28

    2.3 Standardizing terminology 28

    2.4 Microscopic terminology 30

    2.5 Recording pathology data 33

    2.6 Quantitative versus semiquantitative analysis 35

    2.7 Semiquantitative techniques 37

    2.8 Quantitative techniques 38

    References 40

    Chapter 3 Gastrointestinal system 43
    Cheryl L. Scudamore

    3.1 Background and development 43

    3.2 Oral cavity 43

    3.3 Salivary glands 46

    3.4 Stomach and intestines 48

    3.5 Liver 56

    3.6 Pancreas 59

    References 61

    Chapter 4 Cardiovascular system 63
    Cheryl L. Scudamore

    4.1 Background and development 63

    4.2 Sampling techniques and morphometry 63

    4.3 Artefacts 65

    4.4 Anatomy and histology of the heart 67

    4.5 Anatomy and histology of the blood vessels 69

    References 72

    Chapter 5 Urinary system 75
    Elizabeth McInnes

    5.1 Background and development 75

    5.2 Sampling techniques 76

    5.3 Artefacts 76

    5.4 Background lesions 77

    5.5 Anatomy and histology 79

    References 85

    Chapter 6 Reproductive system 87
    Cheryl L. Scudamore

    6.1 Background and development of the male and female reproductive tract 87

    6.2 Female reproductive tract 88

    6.3 Male reproductive tract 97

    References 105

    Chapter 7 Endocrine system 109
    Ian Taylor

    7.1 Introduction 109

    7.2 Adrenals 109

    7.3 Pituitary 114

    7.4 Thyroids and parathyroids 117

    References 121

    Chapter 8 Nervous system 123
    Aude Roulois

    8.1 Introduction 123

    8.2 Necropsy 123

    8.3 Fixation/perfusion 126

    8.4 Trimming 131

    8.5 Special stains and techniques 133

    8.6 Microscopic examination 137

    8.7 Normal histology-juvenile – CNS and PNS 137

    8.8 Artefacts – CNS and PNS 141

    8.9 Pathological changes and background pathology – CNS and PNS 142

    8.10 Acknowledgment 146

    References 146

    Useful website resources 148

    Chapter 9 Lymphoid and haematopoietic system 149
    Ian Taylor

    9.1 Introduction 149

    9.2 Lymph nodes 150

    9.3 Spleen 156

    9.4 MALT (mucosa-associated lymphoid tissue) 160

    9.5 Thymus 161

    9.6 Bone marrow 164

    References 166

    Chapter 10 Integument and adipose tissue 169
    Cheryl L. Scudamore

    10.1 Background and development 169

    10.2 Sampling technique 170

    10.3 Anatomy and histology 171

    References 177

    Chapter 11 The respiratory system 179
    Elizabeth McInnes

    11.1 Background and development 179

    11.2 Embryology 179

    11.3 Anatomy and histology of the respiratory system 180

    11.4 Upper respiratory tract 180

    11.5 Lower respiratory tract 189

    References 193

    Chapter 12 Special senses 195
    Cheryl L. Scudamore

    12.1 Background and development 195

    12.2 Sampling technique for the eye 195

    12.3 Artefacts 197

    12.4 Anatomy and histology of the eye and associated glands 199

    12.5 Background and development of the ear 204

    12.6 Sampling technique for the ear and associated structures 205

    12.7 Anatomy and histology of the ear and associated glands 206

    References 209

    Chapter 13 Musculoskeletal system 211
    Cheryl L. Scudamore

    13.1 Background and development 211

    13.2 Sampling techniques 211

    13.3 Anatomy and histology 212

    References 218

    Index 221


    Author Information
    Cheryl L Scudamore is currently Head of Pathology at Mary Lyon Centre, MRC Harwell and an Honorary Professor in Experimental Pathology at the Royal Veterinary College. She has worked extensively as a pathologist in academia and industry in the UK and is known for her interest in and promotion of postgraduate training in laboratory animal pathology and histological techniques.
 
 
 
 
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