Haschek and Rousseaux's Handbook of Toxicologic Pathology, 4e Volume 3: Environmental Toxicologic Pathology and Major Toxicant Classes

Editors: Wanda Haschek-Hock, Colin Rousseaux, Matthew Wallig, Brad Bolon

No. of pages: 972

Published: February 24, 2023

Imprint: Academic Press

Hardback ISBN: 9780443161537

Description

Haschek and Rousseaux's Handbook of Toxicologic Pathology, Fourth Edition, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive coverage. The fourth edition has been expanded to five separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, this book covers the toxicologic pathology of major classes of environmental toxicants. Volumes emphasize the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity.

This series comprises the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately.

Key features

Provides updated and revised chapters for in-depth discussions of toxicologic pathology for the protection of the environment and food supplies

Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology

Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Readership

Toxicologists, pathologists, and graduate students, in academia, industry and government; environmental scientists; Potential settings include biopharmaceutical, medical device, and chemical companies; contract and basic research organizations; veterinary diagnostic laboratories and medical forensic laboratories; regulatory agencies and universities. Toxicologists, pathologists, and graduate students, in academia, industry and government; environmental scientists; Potential settings include biopharmaceutical, medical device, and chemical companies; contract and basic research organizations; veterinary diagnostic laboratories and medical forensic laboratories; regulatory agencies and universities. Public Health professionals

Table of contents

Cover image

Title page

Table of Contents

Copyright

Dedication

Contributors

About the Editors

Preface

Part 1. Toxicologic Pathology in Environmental and Food Protection

Chapter 1. Environmental Toxicologic Pathology and Human Health

1. Introduction

2. History of Carcinogenic Testing in Animal Species

3. Principles of Evaluations for Carcinogenic Potential

4. Examples of Environmental Pollutants

5. The Role of Lifestyle and the Environment on Human Health

6. Methods of Toxicity and Carcinogenicity Testing

7. Current Considerations for Environmental Toxicity and Carcinogenicity Testing

8. New Directions for Environmental Toxicity and Carcinogenicity Testing

Chapter 2. Food and Toxicologic Pathology

1. Introduction

2. Chemicals Intentionally Added to Food

3. Contamination of Food

4. Compounds with Toxic Properties Naturally Present in Certain Foods

5. Novel Foods

6. Adverse Reactions to Food Constituent

7. Mechanism of Action of Clinical Disorders Related to Food

8. Safety Assessment of Food

9. Regulation of Food

10. Challenges and Future Developments in Food Safety

11. Conclusions

Glossary

Chapter 3. Nutritional Toxicologic Pathology

1. Introduction

2. Caloric Excess and Obesity

3. Caloric Restriction

4. Macronutrients and Micronutrients

5. Dietary Contaminants (Also See Issues In Laboratory Animal Science that Impact Toxicologic Pathology, Vol 1, Chap 29)

Part 2. Selected Toxicant Classes in the Environment

Chapter 4. Herbal Remedies

1. Introduction

2. Apothecary to Pharmacy

3. Evidence for Herbal Remedy Efficacy

4. The Active Pharmaceutical ingredient(s)

5. Quality, Efficacy and Safety

6. Quality

7. Efficacy and Effectiveness

8. Safety

9. Toxicology of Herbal Remedies

10. Toxicologic Pathology of Select Herbal Remedies

11. International Regulatory Overview

12. Discussion

13. Summary

Chapter 5. Phycotoxins

1. Introduction

2. Saxitoxins

3. Cyclic Imines

4. Domoic Acid

5. Brevetoxins

6. Ciguatoxins

7. Okadaic Acid and Dinophysistoxins

8. Azaspiracid Toxins

9. Cylindrospermopsins

10. Microcystins and Nodularins

11. Anatoxins

12. Guanitoxin [Formerly Anatoxin-A(S)]

13. Lyngbyatoxins and Aplysiatoxins

14. β-Methylaminoalanine

15. Emerging Phycotoxins

16. Conclusions and Future Needs

Chapter 6. Mycotoxins

1. Introduction

2. Aflatoxins

3. Ochratoxins

4. Patulin

5. Trichothecene Mycotoxins

6. Zearalenone

7. Fumonisins

8. Ergot Alkaloids

9. Emerging Mycotoxins

10. Summary/Conclusion

Chapter 7. Poisonous Plants

1. Introduction

2. Selected Hepatotoxic Plants

3. Selected Neurotoxic Plants

4. Selected Myotoxic Plants

5. Selected Teratogenic Plants

6. Selected Nephrotoxic Plants

7. Other Toxic Plants

8. Additional Resources

Chapter 8. Animal Toxins

1. Introduction

2. Sources of Exposure

3. Zootoxin Classification

4. Clinical Presentations and Pathologic Manifestations of Zootoxin-Mediated Diseases

5. Diagnosis and Treatment of Zootoxin-Mediated Diseases

6. Regulatory Guidance Regarding Zootoxins

7. Summary

Glossary

Chapter 9. Bacterial Toxins

1. Introduction

2. Exotoxins

3. Endotoxins

4. Clinical Presentations and Pathologic Manifestations of Bacterial Toxin-Mediated Diseases

5. Diagnosis and Treatment of Bacterial Toxin–Mediated Diseases

6. Regulatory Guidance Regarding Bacterial Toxins

7. Summary

Chapter 10. Metals

1. Introduction

2. Antimony

3. Arsenic

4. Beryllium

5. Bismuth

6. Cadmium

7. Chromium

8. Lead

9. Mercury

10. Plutonium (See Also Volume 3, Chap 14, Radiation and Other Physical Agents)

11. Thallium

12. Uranium (See also Volume 3, Chap 14, Radiation and Other Physical Agents)

13. Summary and Conclusions

Chapter 11. Agrochemicals

1. Introduction

2. Herbicides

3. Fungicides

4. Insecticides

5. Rodenticides

6. Conclusions

Chapter 12. New Frontiers in Endocrine Disruptor Research

1. Introduction

2. Environmental Chemicals Can Disrupt Endocrine Signaling

3. Mechanisms of Endocrine Disruption

4. Examples of Disruption of Endocrine Pathways by Some Environmental Contaminants and Emerging Endocrine Disruptors

5. Epigenetic Effects of EDCs

6. From Reactive to Proactive Endocrine Disruptor Analysis

7. Emerging Models in EDC Research

8. Omics Technologies to Evaluate Endocrine Disruption

9. New Frontiers in Bioinformatics and Integrative and Functional Enrichment Omics Approaches

10. Machine Learning and EDCs

11. Conclusions

Abbreviations

Chapter 13. Nanoparticulates

1. Background

2. Experimental Toxicologic Pathology of NPs

3. Future Trends in Nanopathology and Nanotoxicology

4. Conclusions

Chapter 14. Radiation and Other Physical Agents

1. Introduction

Part I Ionizing Radiation

3. Mechanisms of Ionizing Radiation Injury

4. Response to Injury Induced by Ionizing Radiation

Part II Ultraviolet Radiation

6. Mechanisms of Ultraviolet Radiation Injury

7. Response to Injury Induced by Ultraviolet Radiation

Part III Hyperthermia

9. Mechanisms of Hyperthermia-Induced Injury

10. Response to Injury Induced by Hyperthermia

Index

About the editors

Wanda Haschek-Hock

Wanda M. Haschek-Hock, BVSc, Ph.D., is a Diplomate of the American College of Veterinary Pathologists (DACVP), Fellow of the International Academy of Toxicologic Pathology (FIATP), and Honorary Member of the Latin American Society of Toxicologic Pathology. She is Professor Emerita at the University of Illinois College of Veterinary Medicine, Department of Pathobiology. Wanda has over 40 years of experience in comparative, respiratory, and toxicologic pathology with a research focus on natural toxins and food safety. She is a former President of the Society of Toxicologic Pathology (STP) and of the Society of Toxicology’s (SOT) Comparative and Veterinary Specialty Section and has served as an Associate Editor for Toxicological Sciences and Toxicologic Pathology, as Councilor of the American College of Veterinary Pathologists (ACVP), and as Member of the American Board of Toxicology (ABT). She served as an Editor for the three editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseaux’s Handbook of Toxicologic Pathology. She is a recipient of the STP’s Lifetime Achievement Award, the SOT Midwest Regional Chapter’s Kenneth DuBois Award, and the University of Sydney Faculty of Veterinary Science Alumni Award for International Achievement in 2016.

Affiliations and expertise

Professor Emerita, Dept of Veterinary Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

Colin Rousseaux

Colin G. Rousseaux, BVSc, Ph.D., DABT, FIATP, is also a Fellow of the Royal College of Pathology (FRCPath) and Fellow of the Academy of Toxicological Sciences (FATS). He is a Professor (Adjunct) in the Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of Ottawa, Canada. He has over 35 years of experience in comparative and toxicologic pathology with a research focus on herbal remedies, fetal development and teratology, and environmental pollutants. He has described, investigated, and evaluated numerous toxicologic pathology issues associated with pharmaceuticals, pesticides, and agrochemicals. He has served on the editorial board of Toxicologic Pathology. He is a former President of the STP. Colin served as an Editor for the three editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseaux’s Handbook of Toxicologic Pathology.

Affiliations and expertise

Adjunct Professor, Department of Pathology and Laboratory Medicine, University of Ottawa Principal, Colin Rousseaux and Associates, Canada

Matthew Wallig

Matthew A. Wallig, DVM, Ph.D., DACVP, is Professor Emeritus in the Department of Pathobiology, College of Veterinary Medicine, the Department of Food Science and Human Nutrition, as well as the Division of Nutritional Sciences at the University of Illinois. His research has focused on the chemoprotective properties and mechanisms of phytochemicals in the diet, in particular those in cruciferous vegetables, soy, and tomatoes. His current interests have expanded to include defining morphologic parameters for diagnostic quantitative ultrasound in pancreatitis, pancreatic and hepatic neoplasia, metastatic disease, and chronic hepatic diseases such as nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Matt has served as an Editor for the last two editions of the Fundamentals of Toxicologic Pathology and Haschek and Rousseaux’s Handbook of Toxicologic Pathology.

Affiliations and expertise

Professor Emeritus, Department of Veterinary Pathobiology, College of Veterinary Medicine University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

Brad Bolon

Brad Bolon, DVM, MS, Ph.D., DAVCP, DABT, FATS, FIATP, FRCPath, has worked [sic] as an experimental and toxicologic pathologist in several settings: academia, a contract research organization, pharmaceutical companies (in both biomolecule and traditional small molecule settings), and private consulting. His main professional interests are the pathology of genetically engineered mice (especially embryos, fetuses, and placentas) and toxicologic neuropathology to assess the efficacy and safety of many therapeutic entities (biomolecules, cell and gene therapies, medical devices, and small molecules). He is a former President of the STP and a Member of the American College of Toxicology (ACT), British Society of Toxicological Pathology (BSTP), and European Society of Toxicologic Pathology (ESTP). Brad served as an Editor for the third edition of the Fundamentals of Toxicologic Pathology and an Associate Editor for the third edition of Haschek and Rousseaux’s Handbook of Toxicologic Pathology.

Affiliations and expertise

President and Pathologist, GEMpath, Inc., Longmont, Colorado, USA