Diagnostic Pathology: Blood and Bone Marrow, 3rd Edition

Main Author : By Kathryn Foucar, MD

ISBN : 9780323878784

Imprint : Elsevier

Trim : 216w x 276h

Illustrations : Features nearly 2,600 superb images (many new or updated), including histology and gross pathology photographs, full-color illustrations and schematics, clinical photographs, and radiologic images

Publication Date : Sep 2023

Page : 950

Description

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the full range of nonneoplastic and neoplastic conditions of blood and bone marrow, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Blood and Bone Marrow is a visually stunning, one-stop resource for every practicing pathologist, hematopathologist, oncologist, hematologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource. 

Key Features

• Provides practicing pathologists with key details about new entities, newly recognized causes of morphologic change in blood and bone marrow abnormalities, and new strategies for appropriate workup of neoplastic processes—all with a focus on key tests and key differential diagnostic considerations

• Helps pathologists recognize unique blood and bone marrow findings that can be an indicator for specific exposures, such as new medications, new targeted therapies, or toxins

• Integrates updated technologies, newly recognized disorders, complications/features in blood and bone marrow, new targeted therapies, and the increased use of homeopathic remedies

• Contains new chapters covering SARS-CoV-2 infection features in blood and bone marrow, myelodysplastic syndrome (MDS) mimics, blood and bone marrow findings linked to targeted therapies, blood and bone marrow findings linked to other medications, and more

• Updates all existing chapters and contains expanded information on T-cell neoplasms in blood and bone marrow and intravascular large B-cell lymphoma in blood and bone marrow

• Includes details from the World Health Organization (WHO) fifth edition Classification of Haematolymphoid Tumours and the very latest 2023 International Consensus Classification (ICC) publications, reflecting new and renamed diagnostic entities, tumor classification changes and updates, and terminology changes and updates

• Discusses molecular testing strategies based on specific neoplasms and specific differential diagnostic consideration

• Clearly delineates numerous genetic disorders often found in blood and bone marrow

• Features more than 2,500 superb images, including histology and gross pathology photographs, full-color illustrations and graphics, clinical photographs and radiologic images, and many new tables and charts/algorithms

• Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care

• Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices

Table Of Contents

SECTION 1: INTRODUCTION

4 Hematopoiesis and Bone Marrow Histology

14 Bone Marrow Examination and Techniques

26 Synoptic/Integrated Bone Marrow Reporting and Algorithmic Testing

30 Overview of Constitutional and Acquired Bone Marrow Disorders

SECTION 2: ANEMIA

38 Overview of Anemia

ACQUIRED ANEMIAS

44 Anemias of Inflammation, Chronic Kidney Disease, and Cancer

48 Iron Deficiency Anemia

52 Autoimmune Hemolytic Anemias

58 Alloimmune Hemolytic Anemia and Hemolytic Disease of Newborn

62 Microangiopathic Hemolytic Anemia

68 Megaloblastic Anemia

76 Acquired Nonneoplastic Sideroblastic Anemia

80 Alcoholism-Associated Anemia

84 Anemia in Older Adults

88 Copper Deficiency-Associated Anemia

92 Acquired Red Cell Aplasia

96 Transient Erythroblastopenia of Childhood

98 Parvovirus-Induced Red Cell Aplasia

102 Paroxysmal Nocturnal Hemoglobinuria

108 Acquired Aplastic Anemia

CONSTITUTIONAL ANEMIAS

112 Thalassemia

118 Sickle Cell Anemia

122 Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency

124 Pyruvate Kinase Deficiency

126 Hereditary Spherocytosis

132 Hereditary Elliptocytosis, Including Hereditary Pyropoikilocytosis

136 Diamond-Blackfan Anemia

140 Fanconi Anemia

144 Congenital Dyserythropoietic Anemia

150 Congenital Sideroblastic Anemia

154 Congenital Megaloblastic Anemia

SECTION 3: ERYTHROCYTOSIS

CONSTITUTIONAL

162 Congenital Erythrocytosis

ACQUIRED

166 Acquired Erythrocytosis

SECTION 4: BENIGN LEUKOCYTE DISORDERS IN BLOOD AND BONE MARROW

172 Overview of Benign Leukocyte Disorders in Blood and Bone Marrow

176 Pancytopenia

184 Neutropenia

190 Neutrophilia

196 Monocytosis

202 Eosinophilia

210 Basophilia

212 Lymphocytosis

216 Lymphopenia, Constitutional and Acquired

220 Plasmacytosis of Bone Marrow

228 Hematogones in Bone Marrow

238 Lymphoid Aggregates in Bone Marrow

246 Granulomas in Bone Marrow

SECTION 5: CONSTITUTIONAL GRANULOCYTIC DISORDERS

CONSTITUTIONAL NEUTROPENIAS

254 Severe Congenital Neutropenia and Cyclic Neutropenia

258 Shwachman-Diamond Syndrome

262 Chediak-Higashi Syndrome

266 Myelokathexis in WHIM Syndrome

CONSTITUTIONAL NEUTROPHIL ANOMALIES

270 Pelger-Huët Anomaly

274 MYH9-Related Disorders

278 Selected Lysosomal Storage Diseases With Abnormal Leukocyte Granulation

SECTION 6: MEGAKARYOCYTIC DISORDERS

286 Overview of Megakaryocytic Disorders

ACQUIRED PLATELET DISORDERS WITH THROMBOCYTOPENIA

296 Immune-Mediated Thrombocytopenia

302 Hemolytic Uremic Syndrome

308 Heparin-Induced Thrombocytopenia (HIT)

312 Thrombotic Thrombocytopenic Purpura

316 Pregnancy-Associated Thrombocytopenia

CONSTITUTIONAL PLATELET DISORDERS WITH THROMBOCYTOPENIA

320 Thrombocytopenia Absent Radius Syndrome

324 Congenital Amegakaryocytic Thrombocytopenia

328 Gray Platelet Syndrome

332 Wiskott-Aldrich Syndrome-Related Disorders

336 Congenital Thrombotic Thrombocytopenic Purpura

THROMBOCYTOSIS

340 Thrombocytosis

SECTION 7: INFECTIONS

346 Overview of Infections

350 Hantavirus Pulmonary Syndrome

354 Human Immunodeficiency Virus

364 Infectious Mononucleosis Syndromes (Epstein-Barr Virus, Cytomegalovirus)

374 Parvovirus B19 Infection

378 Bacterial Infections, Blood and Bone Marrow Features

388 Fungal Infections, Blood and Bone Marrow Features

394 Helminthic Infections

398 Malaria

406 Other Protozoan Infections

412 COVID-19 Infection (SARS-CoV-2)

SECTION 8: MISCELLANEOUS NONNEOPLASTIC DISORDERS AND CONDITIONS

418 Overview and Classification of Hemophagocytic Disorders in Bone Marrow

426 Hematologic Manifestations of Collagen Vascular Disorders

432 Hematologic Manifestations of Chronic Kidney Disease

434 Lysosomal Storage Diseases With Predominantly Histiocytic Storage

440 Homeopathic Remedies and Medications Affecting Blood and Bone Marrow Morphology

444 Other Pregnancy-Associated Hematologic Disorders

448 VEXAS Syndrome

452 Gelatinous Transformation and Other Bone Marrow

Stromal Disorders

456 Bone Marrow Necrosis

460 Crystals in Bone Marrow

466 Bone Abnormalities in Bone Marrow Specimens

SECTION 9: MYELOID NEOPLASMS

476 Overview and Classification of Myeloid Neoplasms

482 Specialized Testing in Myeloid Neoplasms

MYELOPROLIFERATIVE NEOPLASMS

484 Overview of Myeloproliferative Neoplasms

488 Chronic Myeloid Leukemia

498 Chronic Neutrophilic Leukemia

506 Polycythemia Vera

512 Primary Myelofibrosis

522 Essential Thrombocythemia

530 Chronic Eosinophilic Leukemia, Not Otherwise Specified

538 Myeloproliferative Neoplasm, Unclassifiable

MASTOCYTOSIS

544 Systemic Mastocytosis

554 Mast Cell Leukemia

MYELOID/LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND TYROSINE KINASE GENE FUSIONS

562 Myeloid/Lymphoid Neoplasms With Eosinophilia and PDGFRA

564 Myeloid/Lymphoid Neoplasms With Eosinophilia and PDGFRB

566 Myeloid/Lymphoid Neoplasms With Eosinophilia and FGFR1

568 Myeloid/Lymphoid Neoplasms With Eosinophilia and FLT3 and Other Uncommon Fusion Genes

MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASMS

570 Overview of Myelodysplastic/Myeloproliferative Neoplasms

574 Chronic Myelomonocytic Leukemia and Precursor Lesions

578 Atypical Chronic Myeloid Leukemia

582 Myelodysplastic/Myeloproliferative Neoplasm With and Without SF3B1 Mutation and Thrombocytosis

586 Myelodysplastic/Myeloproliferative Neoplasms, Not Otherwise Specified, and Provisional Entity

MYELODYSPLASTIC SYNDROMES

588 Overview and Classification of Myelodysplastic Syndromes

598 Myelodysplastic Syndrome Precursor Lesions

600 Myelodysplastic Syndromes With Mutated SF3B1

604 Myelodysplastic Syndrome With del(5q)

612 Myelodysplastic Syndrome With Multihit TP53 Mutation

614 Myelodysplastic Syndromes, Not Otherwise Specified

620 Myelodysplastic Syndromes With Excess Blasts

624 Myelodysplastic Syndrome/Acute Myeloid Leukemia

628 Mimics of Myelodysplasia

HEMATOLOGIC NEOPLASMS WITH GERMLINE PREDISPOSITION, PEDIATRIC MYELODYSPLASTIC SYNDROME, AND JUVENILE MYELOMONOCYTIC LEUKEMIA

632 Juvenile Myelomonocytic Leukemia and Similar Neoplasms

636 Pediatric Myelodysplastic Syndrome (Refractory Cytopenia of Childhood)

642 Hematologic Neoplasms With Germline Predisposition

644 Myeloid Proliferations Related to Down Syndrome

ACUTE MYELOID LEUKEMIA

648 Overview of Acute Myeloid Leukemia

656 Acute Promyelocytic Leukemia With t(15;17)(q24.1;q21.2)/PML::RARA

662 Acute Promyelocytic Leukemia With Other RARA Rearrangements

664 Acute Myeloid Leukemia With t(8;21)(q22;q22.1)/RUNX1::RUNX1T1

674 Acute Myeloid Leukemia With inv(16)(p13.1q22) or t(16;16)(p13.1;q22)/CBFB::MYH11

682 Acute Myeloid Leukemia With t(9;11)(p21.3;q23.3)/MLLT3::KMT2A and Other

KMT2A Rearrangements

690 Acute Myeloid Leukemia With Mutated TP53

694 Acute Myeloid Leukemia With Uncommon Cytogenetic Abnormalities

698 Acute Myeloid Leukemia With Myelodysplasia-Related Gene Mutations or Cytogenetic Abnormalities

704 Acute Myeloid Leukemia, Not Otherwise Specified

708 Acute Leukemia of Ambiguous Lineage

714 Measurable Residual Disease Testing Strategies in

Acute Myeloid Leukemia

BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM

718 Blastic Plasmacytoid Dendritic Cell Neoplasm

SECTION 10: LYMPHOID NEOPLASMS

728 Overview of Lymphoid Neoplasms

734 Specialized Testing in Lymphoid Neoplasms

B-PRECURSOR NEOPLASMS

738 B-Acute Lymphoblastic Leukemias: Cytogenetic Subtypes and Not Otherwise Specified (ICC)

746 B-Acute Lymphoblastic Leukemia, BCR::ABL1-Like

750 Novel Genetic Subtypes of B-Acute Lymphoblastic Leukemia

754 Measurable Residual Disease Testing Strategies in Acute Lymphoblastic Leukemia

T-PRECURSOR NEOPLASMS

756 T- and NK-Cell Acute Lymphoblastic Leukemia (ICC)

762 Early T-Cell Precursor Acute Lymphoblastic Leukemia

MATURE B-CELL NEOPLASMS

764 Overview and Classification of Mature B-Cell Leukemias, Immunosecretory Neoplasms

772 Monoclonal B-Cell Lymphocytosis

776 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

786 B-Cell Prolymphocytic Leukemia

788 Splenic Marginal Zone Lymphoma

794 Hairy Cell Leukemia

804 Splenic B-Cell Leukemia, Hairy Cell Leukemia Variant

806 Lymphoplasmacytic Lymphoma

812 ?-Heavy Chain Disease

816 Monoclonal Gammopathy

822 Multiple Myeloma

834 Burkitt Lymphoma

842 Mantle Cell Lymphoma in Blood and Bone Marrow

846 Follicular Lymphoma in Blood and Bone Marrow

850 Marginal Zone Lymphoma in Blood and Bone Marrow

854 Intravascular Large B-Cell Lymphoma

858 Other Large B-Cell Lymphomas in Blood and Bone Marrow

MATURE T-/NK-CELL NEOPLASMS

860 Overview and Classification of Mature T-/NK-Cell Neoplasms in Blood and Bone Marrow

864 T-Cell Prolymphocytic Leukemia

870 T-Cell Large Granular Lymphocytic Leukemia

876 Chronic Lymphoproliferative Disorder of NK Cells

878 Aggressive NK-Cell Leukemia

882 Adult T-Cell Leukemia

884 Sézary Syndrome

890 Anaplastic Large Cell Lymphoma in Blood and Bone Marrow

896 Angioimmunoblastic T-Cell Lymphoma in Blood and Bone Marrow

898 Other Mature T-Cell Lymphomas Involving Blood and Bone Marrow

HODGKIN LYMPHOMA IN BONE MARROW

902 Classic Hodgkin and Nodular Lymphocyte-Predominant B-Cell Lymphomas in Bone Marrow

SECTION 11: OTHER NEOPLASMS INVOLVING BONE MARROW

910 Langerhans Cell Histiocytosis in Bone Marrow

914 Posttransplant Lymphoproliferative Disorders in Bone Marrow

920 Metastatic Carcinoma and Sarcoma

Author Information

By Kathryn Foucar, MD, Distinguished Professor Emerita of Pathology, Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico