• Provides background material for students to understand the broader backdrop against which animal research is undertaken
• Includes ethical and regulatory information
• Covers commonly used animal models and the process to choose a model for biomedical research

Early researchers, undergraduate and graduate students, researchers and professors studying laboratory animal research; technicians in laboratory animal science; pre-veterinarians and veterinarians; and students/early researchers working with laboratory animals across biological and biomedical research

• Preface
• Chapter 1. Brief Historical Overview on the Use of Animals in Research
  • 1.1. Introduction
  • 1.2. Early Attitudes Toward Animal Health and Disease
  • 1.3. Development and Emergence of New Animal Models
  • 1.4. Improvements in Approaches to Animal Care
  • 1.5. Summary
• Chapter 2. Philosophical and Ethical Foundations
  • 2.1. Basic Approaches
  • 2.2. Animal Welfare Versus Animal Rights
  • 2.3. Opposition to and Benefits of Animal Experimentation
  • 2.4. Professional Ethics Relating to Biomedical Research
• Chapter 3. Regulations and Guidelines
  • 3.1. Introduction
  • 3.2. US Animal Welfare Act
  • 3.3. Public Health Service Policy
  • 3.4. FDA Good Laboratory Practices
  • 3.5. Other Laws, Regulations, and Policies
  • 3.6. Fish and Wildlife Service and NIH Positions on Chimpanzees
  • 3.7. Professional and Scientific Associations
  • 3.8. International Laws and Regulations
  • 3.9. Conclusions
• Chapter 4. Institutional Animal Care and Use Committee
  • 4.1. Purpose and Function
  • 4.2. Committee Composition
  • 4.3. IACUC Review of Proposed Activities and Projects
  • 4.4. Periodic Review of the Animal Care and Use Program and Facilities
  • 4.5. Investigation of Concerns Regarding the Use and Treatment of Vertebrate Animals
  • 4.6. Sample Size Estimation in Laboratory Animal Experiments
• Chapter 5. Experimental Variables
  • 5.1. The Research Environment
  • 5.2. Environmental Enrichment
  • 5.3. Animal Health Monitoring Program
  • 5.4. Summary
• Chapter 6. Model Selection
  • 6.1. Selection Criteria
  • 6.2. Types of Models
  • 6.3. Spontaneous Mutation Models
  • 6.4. Random Mutation Models
  • 6.5. Genetically Manipulated Models
  • 6.6. Chemically Induced Models
  • 6.7. Physically Induced Models
  • 6.8. Surgical Models
  • 6.9. Behavioral Models
  • 6.10. Production Models
• Chapter 7. Commonly Used Animal Models
  • 7.1. The Mouse
  • 7.2. The Rat
  • 7.3. The Rabbit
  • 7.4. Zebrafish
  • 7.5. Amphibians and Reptiles
  • 7.6. Birds
  • 7.7. Other Small Mammals
  • 7.8. Summary
• Chapter 8. Common Technical Procedures in Rodents
  • 8.1. Handling and Restraint Methods
  • 8.2. Identification
  • 8.3. Common Technical Procedures
  • 8.4. Rodent Anesthesia
  • 8.5. Rodent Surgery
  • 8.6. Euthanasia
  • 8.7. Necropsy
  • 8.8. Summary
• Chapter 9. Considerations for Use of Vertebrates in Field Studies
  • 9.1. Reasons for Conducting Field Research
  • 9.2. Sources for Specific Technique Information
  • 9.3. Initial Steps for Undertaking Field Research Involving Vertebrates
  • 9.4. Observational Techniques
  • 9.5. Capturing Animals
  • 9.6. Handling Animals
  • 9.7. Identification and Marking of Animals
  • 9.8. Conclusion
• Chapter 10. Personnel Safety in the Care and Use of Laboratory Animals
  • 10.1. Introduction
  • 10.2. Occupational Health and Safety Programs
  • 10.3. Hazards Associated With Animal Research
  • 10.4. Best Practices for Prevention
  • 10.5. Conclusions: Personnel Engagement and Awareness
• Chapter 11. Thesis Development
  • 11.1. Preparation
  • 11.2. Thesis Sections
  • 11.3. Finalizing the Thesis
  • 11.4. Conclusion
• Glossary of Terms and Acronyms
• Index