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Fish Net

Description

Zebrafish are widely considered an excellent model system for vertebrate development. The embryo is transparent, thereby enabling visualization and use of labelling and transgenic approaches. Moreover, because of the ease of inducing new mutations in zebrafish and similarity with the human genome, this organism may be used effectively for disease studies. For example, mutant zebrafish are being utilized for testing drugs that will combat a range of human diseases, from Alzheimer's and cancer to kidney failure and congenital heart disease. For the first time, this atlas provides the research community with a complete reference for zebrafish anatomy spanning the early embryo all the way to adulthood.

The authors employ the technique of optical projection tomography (OPT), and offer a series of sections in multiple planes from each sample. The contents are organized by developmental stages, with over 200 images that contain annotations describing anatomical structures relevant to development. In addition, chapters feature explanatory text that highlights major developments in the zebrafish during each stage.

Readership

This Atlas will be an essential reference for researchers in a range of disciplines, both academic and commercial, working with zebrafish as a model system for development and/or human disease. It will also be useful as a resource for students in developmental biology, molecular genetics, toxicology, anatomical physiology, embryology, etc.

Contents

I. Introduction

Chapter 1. Introduction

Chapter 2. FishNet: An Interactive Database of Zebrafish Development

Chapter 3. Methodology and Interpretation of the Atlas

II. The Early Embryo

Chapter 4. 24hours

Chapter 5. 48 hours

Chapter 6. 72 hours

Chapter 7. 96 hours

Chapter 8. 120 hours

III. The Developing Larvae

Chapter 9. 5-7mm

Chapter 10. 8-10mm

Chapter 11. 10-14mm

IV. The Adult Zebrafish

Chapter 12. 15-17mm

Author Information

By Robert Bryson-Richardson; Silke Berger and Peter Currie