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Á¶Á÷/º´¸®ÇÐ > Pathology > Diagnostic Pathology: Molecular Oncology, 2nd Edition(Á¾ÀÌÃ¥+eBook)

 
Diagnostic Pathology: Molecular Oncology, 2nd Edition(Á¾ÀÌÃ¥+eBook)
»óÇ°¸í : Diagnostic Pathology: Molecular Oncology, 2nd Edition(Á¾ÀÌÃ¥+eBook)
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Diagnostic Pathology: Molecular Oncology, 2nd Edition



Main Author : By Mohammad A. Vasef, MD and Aaron Auerbach, MD, MPH

Illustrations : Approx. 2700 full-color illustrations

Trim : 276 x 216 (8 1/2 x 10 7/8)

Imprint : Elsevier

Copyright Year : Jul 2019

ISBN : 9780323611442

Page : 1016



Description


Covering all aspects of molecular pathology as it relates to the transformation and pathogenesis of cancer, this award-winning volume in the Diagnostic Pathology¡¡series is an expert resource for pathologists at all levels of experience and training, both as a quick reference and as an efficient review to improve knowledge and skills. This easily accessible, point-of-care reference features templated, bulleted content that is generously illustrated with charts, graphs, tables, and color photomicrographs of histology with special stains. It offers a practical, clinical approach to examining how molecular mutations affect common medical diseases and identifies the relevant and appropriate molecular tests to perform for a complete work-up in the era of molecular-targeted therapies.



Key Features


  • Provides updated information on molecular mutations in different tumors, including solid tumors and hematopoietic neoplasms, and new targeted therapies geared toward these molecular alterations
  •  

  • Discusses now widely used immunotherapy treatments, including how immunotherapy has revolutionized the treatment of many neoplasms such as breast and lung carcinomas and lymphoma
  •  

     

  • Features more than 2,000 annotated images throughout, including H&E stains, immunostains, and FISH images
  •  

     

  • Covers timely topics such as:
  •  

    • Recent advances in cancer immunotherapy, specifically in the molecular basis of immunotherapy
    • Newly discovered targeted therapies, including multiple lung carcinoma therapies now considered for patients based on existing mutations to specific genes (KRAS, ALK, BRAF, and ROS)
    • The need for integration of myeloid and lymphoid gene panels due to increased knowledge from next generation sequencing studies of new mutations and the resulting newly developed molecular targets
    • Increased usage of next generation sequencing techniques
    • Changes to hematopoietic tumor details based on revised WHO guidelines

     

  • Recipient of a 2016 BMA Award: Highly Commended, Pathology (previous edition)
  •  


  • Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices


  • Table of Contents


    DP2 Molecular Oncology: Auerbach and Vasef

    Introduction

    Structure of Chromosomes and Nucleic Acids

    DNA Replication, Transcription, and Translation

    Gene Mutations

    Common Techniques for Analysis of Alterations in Chromosomes and DNA

    Cytogenetics and FISH

    Chromosomal Microarray

    Amplification Methods

    DNA High-Resolution Melting Curve Analysis

    Sequencing Technologies

    High-Throughput Methods in Molecular Pathology

    DNA Methylation Analysis

    Molecular Genetic Tests in Hematopoietic Tumors

    *BCR-ABL1* Fusion Gene

    *PDGFRA*, *PDGFRB*, and *FGFR1* Rearrangements Detection

    PML-RARA Fusion Gene

    Reverse Transcription PCR for Other Myeloid Leukemia Transcripts

    FLT3, NPM1, and CEBPA Mutations

    JAK2 Mutations and Rearrangements

    MPL Mutations

    Calreticulin (CALR) Mutations

    CSF3R Mutations

    SETBP1 Mutations

    KIT Mutations

    IDH1 and IDH2 Mutations

    Other Mutations and Gene Panel Testing in Myeloid Neoplasms

    Immunoglobulin Heavy (IGH) Chain Gene Rearrangements

    T-Cell Receptor Gamma (TRG) and Delta (TRD) Chain Rearrangements

    T-Cell Receptor Beta (TRB) Chain Gene Rearrangements

    Southern Blot Analysis of Antigen Receptor Genes

    EBV-Associated Human Neoplasms

    MYD88 Mutation

    NOTCH1 Mutation

    EZH2 Mutation

    Molecular Genetic Tests in Solid Tumors, Bone and Soft Tissue Tumors, and CNS Tumors

    ALK Gene Rearrangements and Mutations

    FISH for ROS1 Rearrangements

    RET Rearrangements

    FISH for MET Amplifications

    FISH for ERBB2 (HER2) Gene Amplifications

    KRAS Mutations

    BRAF Mutations

    EGFR Mutations

    Targeted Hotspot Gene Panel Using Massively Parallel Sequencing (Next Generation Sequencing)

    Targeted Hotspot Gene Panel Table

    MGMT Promoter Gene Methylation Assay

    MET Exon 14 Skip Mutations

    NGS Panels for NCI MATCH

    FISH for 1p/19q Deletions

    IDH1 and IDH2 Mutations

    Molecular Basis of Immunotherapy in Cancer

    Molecular Pathology of Myeloid Neoplasms

    Molecular Pathology of Myeloid Neoplasms

    Molecular Work-Up of Myeloid Neoplasms

    Myeloproliferative Neoplasms

    Chronic Myeloid Leukemia, BCR-ABL1 Positive

    Chronic Neutrophilic Leukemia

    Polycythemia Vera

    Primary Myelofibrosis

    Essential Thrombocythemia

    Chronic Eosinophilic Leukemia, NOS

    Mastocytosis

    Myeloproliferative Neoplasms, Unclassifiable

    Mastocytosis

    Myeloid/Lymphoid Neoplasms With PDGFRA Rearrangement

    Myeloid/Lymphoid Neoplasms With PDGFRB Rearrangement

    Myeloid/Lymphoid Neoplasms With FGFR1 Rearrangement

    Myeloid/Lymphoid Neoplasms With PCM1-JAK2

    Myelodysplastic Syndrome (MDS)

    Overview and Classification of MDS

    Myelodysplastic Syndromes With Single Lineage Dysplasia

    Myelodysplastic Syndrome With Ring Sideroblasts

    Myelodysplastic Syndrome With Multilineage Dysplasia

    Myelodysplastic Syndrome With Excess Blasts

    Myelodysplastic Syndrome With Excess Blasts and Erythroid Predominance

    Myelodysplastic Syndrome With Excess Blasts and Fibrosis

    Myelodysplastic Syndrome With Isolated del(5q)

    Myelodysplastic Syndrome, Unclassifiable

    Childhood Myelodysplastic Syndrome and Refractory Cytopenia of Childhood

    Myelodysplastic/Myeloproliferative Neoplasms

    Overview of Myelodysplastic/Myeloproliferative Neoplasms

    Chronic Myelomonocytic Leukemia

    Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative

    Juvenile Myelomonocytic Leukemia

    Myelodysplastic/Meloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis

    Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable

    Myeloid Neoplasms With Germline Predisposition

    Acute Myeloid Leukemia

    Overview of Acute Myeloid Leukemia

    Acute Myeloid Leukemia With t(8;21); RUNX1-RUNX1T1

    Acute Myeloid Leukemia With inv(16) or t(16;16); CBFB-MYH11

    Acute Promyelocytic Leukemia With t(15;17); PML-RARA

    Acute Myeloid Leukemia With t(9;11); MLLT3-KMT2A

    Acute Myeloid Leukemia With t(6:9); DEK-NUP214

    Acute Myeloid Leukemia With inv(3) or t(3;3); RPN1-MECOM

    Acute Myeloid Leukemia (Megakaryoblastic) With t(1;22); RBM15-MKL1

    Acute Myeloid Leukemia With BCR-ABL1

    Acute Myeloid Leukemia With Gene Mutations

    Acute Myeloid Leukemia With Mutated NPM1

    Acute Myeloid Leukemia With Biallelic Mutation of CEBPA

    Acute Myeloid Leukemia With Mutated RUNX1

    Acute Myeloid Leukemia With Myelodysplasia-Related Changes

    Acute Myeloid Leukemia, NOS

    Therapy-Related Myeloid Neoplasms

    Myeloid Sarcoma

    Myeloid Proliferations Associated With Down Syndrome

    Blastic Plasmacytoid Dendritic Cell Neoplasm

    Blastic Plasmacytoid Dendritic Cell Neoplasm

    Acute Leukemias of Ambiguous Lineage

    Overview of Ambiguous Lineage Leukemias

    Acute Undifferentiated and Mixed Phenotype Acute Leukemias

    Molecular Pathology of Lymphoid Neoplasms

    Overview of Lymphoid Neoplasms

    Molecular Work-Up of Lymphoid Neoplasms

    Precursor Lymphoid Neoplasms

    B-Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified

    B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormalities

    B-Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like

    T-Lymphoblastic Leukemia/Lymphoma

    Mature B-Cell Neoplasms

    Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia

    Monoclonal B-Cell Lymphocytosis

    B-Cell Prolymphocytic Leukemia

    Splenic Marginal Zone Lymphoma

    Hairy Cell Leukemia

    Splenic B-Cell Lymphoma/Leukemia, Unclassifiable

    Lymphoplasmacytic Lymphoma

    IgM Monoclonal Gammopathy of Undetermined Significance

    Heavy Chain Disease

    ¥ì-Heavy Chain Disease

    ¥ã-Heavy Chain Disease

    ¥á-Heavy Chain Disease

    Plasma Cell Myeloma

    Marginal Zone Lymphoma

    Follicular Lymphoma

    Large B-Cell Lymphoma With IRF4 Rearrangement

    Mantle Cell Lymphoma

    Diffuse Large B-Cell Lymphoma

    T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

    Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation

    Burkitt Lymphoma

    High-Grade B-Cell Lymphoma

    Mature T- and NK-Cell Neoplasms

    T-Cell Prolymphocytic Leukemia

    Chronic Lymphoproliferative Disorder of NK Cells

    Aggressive NK-Cell Leukemia

    Extranodal NK-/T-Cell Lymphoma, Nasal Type

    Adult T-Cell Leukemia/Lymphoma

    Intestinal T-Cell Lymphoma

    Hepatosplenic T-Cell Lymphoma

    Subcutaneous Panniculitis-Like T-Cell Lymphoma

    Mycosis Fungoides/Sezary Syndrome

    Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders

    Primary Cutaneous Peripheral T-Cell Lymphoma, Rare Subtypes

    Peripheral T-Cell Lymphoma, Not Otherwise Specified

    Angioimmunoblastic T-Cell Lymphoma

    Anaplastic Large Cell Lymphoma, ALK-Negative

    Anaplastic Large Cell Lymphoma, ALK-Positive

    Breast Implant-Associated Anaplastic Large Cell Lymphoma

    Determination of Clonality in B-, T-, and NK-Cell Neoplasms

    Lymphoma-Associated Chromosomal Translocations

    Molecular Pathology of Dendritic Cell and Histiocytic Neoplasms

    Histiocytic Sarcoma

    Tumors Derived From Langerhans Cells

    Interdigitating Dendritic Cell Tumor

    Interdigitating Dendritic Cell Sarcoma

    Follicular Dendritic Cell Neoplasm

    Fibroblastic Reticular Cell Tumor

    Disseminated Juvenile Xanthogranuloma

    Erdheim-Chester Disease

    Molecular Pathology of Solid Tumors

    Head and Neck, Including Sinonasal Tumors and Salivary Glands

    HPV-Related Squamous Cell Carcinoma

    Head and Neck Mucosal Squamous Cell Carcinoma, Non-HPV-Related

    Important Alterations in Non-HPV-Related Head & Neck SCC

    Translocation-Specific Salivary Gland Tumors

    Nasopharyngeal EBV-Related Squamous Carcinoma

    Other Head and Neck Tumors

    Thyroid

    Papillary Thyroid Carcinoma

    Follicular Thyroid Carcinoma

    Poorly Differentiated Thyroid Carcinoma

    Undifferentiated Thyroid Carcinoma

    Medullary Thyroid Carcinoma

    Lung

    Adenocarcinoma, Lung

    Squamous Cell Carcinoma, Lung

    Small Cell Neuroendocrine Carcinoma

    Mesothelioma

    Luminal GI Tract

    Gastric Adenocarcinoma

    Colorectal Adenocarcinoma and Precancerous Lesions

    Gastrointestinal Stromal Tumor

    Liver

    HNF1¥á-Inactivated Hepatocellular Adenoma

    ¥â-Catenin-Activated Hepatocellular Adenoma

    Inflammatory Hepatocellular Adenoma

    Hepatocellular Carcinoma

    Pancreaticobiliary

    Pancreatic Ductal Adenocarcinoma

    Pancreatic Mucinous Cystic Neoplasm

    Pancreatic Intraductal Papillary Mucinous Neoplasm

    Cholangiocarcinoma

    Testis

    Testicular Germ Cell Tumors

    Kidney

    Clear Cell Renal Cell Carcinoma

    Chromophobe Renal Cell Carcinoma

    Papillary Renal Cell Carcinoma

    MiT Family Translocation Renal Cell Carcinoma

    Wilms Tumor

    Clear Cell Sarcoma of Kidney

    Oncocytoma

    Rhabdoid Tumor of Kidney

    Bladder

    Urothelial Carcinoma

    Adrenal

    Pheochromocytoma/Paraganglioma

    Adrenal Cortical Carcinoma

    Neuroblastoma

    Adrenal Cortical Adenoma

    Prostate

    Prostatic Adenocarcinoma, Acinar Type and High-Grade Prostatic Intraepithelial Neoplasia

    Breast

    ADH and DCIS (Dysplastic, Premalignant)

    Ductal Carcinomas

    Lobular Carcinoma

    Carcinoma With Medullary Features, Breast

    Metaplastic Breast Carcinoma

    Phyllodes Tumors

    Basal-Like and Triple-Negative Carcinomas

    Cervix/Vulva/Vagina

    Preneoplastic Conditions, Cervix/Vulva/Vagina

    Squamous Cell Carcinoma, Cervix/Vulva/Vagina

    Adenocarcinoma, Cervix/Vulva/Vagina

    Uterus

    Endometrial Intraepithelial Neoplasia

    Uterine Endometrioid Carcinoma

    Uterine Serous Carcinoma

    Clear Cell Carcinoma, Uterus

    Uterine Sarcomas

    Ovaries/Fallopian Tube

    Serous Tumors of Ovary and Fallopian Tube

    Other Surface Epithelial Tumors of the Ovary

    Sex Cord-Stromal Tumors of the Ovary

    Germ Cell Tumor, Ovary

    Skin

    Preneoplastic Conditions, Skin

    Melanoma

    Squamous Cell Carcinoma, Skin

    Basal Cell Carcinoma, Skin

    Other Skin Conditions

    Bone

    Osteosarcomas

    Overview of Molecular Pathology of Bone and Soft Tissue Tumors

    Ewing Sarcoma

    Other Small Round Blue Cell Sarcomas

    Giant Cell Tumor of Bone

    Intermediate and Malignant Cartilaginous Tumors of Bone

    Soft Tissue

    Overview

    Intermediate and Malignant Myofibroblastic/Fibroblastic Tumors

    Liposarcomas

    Muscle Sarcomas

    Intermediate and Malignant Vascular Tumors

    Malignant Peripheral Nerve Sheath Tumor

    Representative Genetic Findings in Bone and Soft Tissue Tumors

    Sarcomas of Uncertain Differentiation

    Rare Sarcomas of Uncertain Differentiation With Specific Molecular Alterations

    CNS

    High-Grade Astrocytoma

    Low-Grade Astrocytoma

    Pilocytic Astrocytoma

    Oligodendroglioma

    Ependymoma

    Medulloblastoma

    Choroid Plexus Tumors

    Meningioma

    Retinoblastoma

    Quality Assurance and Regulatory Issues

    Federal Agencies and Regulation of Laboratories

    FDA Regulations

    Proficiency Testing and Accreditation



    Author Information


    By Mohammad A. Vasef, MD, Professor of Pathology, The University of New Mexico Health Sciences Center, Albuquerque, New Mexico and Aaron Auerbach, MD, MPH, Staff Pathologist, Department of Hematopathology, The Joint Pathology Center, Bethesda, Maryland




     
     
     
     
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