Imprint: Academic Press

Published Date: January 2021                

Page Count: 448

Stem Cells: Scientific Facts and Fiction, Third Edition, provides a state-of-the-art overview on the field of stem cells and their current applications. The book incorporates the history and firsthand commentaries in the field from clinical and research leaders, covering interesting topics of note, including the first clinical trials to treat Parkinson disease, macular degeneration, and corneal replacement, the cloning of monkeys, the organoid field, and CRISPR-edited genomics. In addition, coverage of adult, embryonic stem cells and iPS cells is included. This new edition distinguishes itself from the multiplicity of websites about stem cells with a broad view of the field.

• Explains, in a straightforward, nonspecialist language, the basic biology of stem cells and their applications in modern medicine and future therapy
• Provides new and expanded coverage of cloning, organoids, “synthetic” embryos, and much more
• Includes detailed illustrations to assist users with learning on how research is done

Biotech and biomedical researchers who need to understand stem cells to enhance their work and extend collaborations; specialists in all medical disciplines

1. The Biology of the Cell

2. Embryonic Development

3. What are Stem Cells?

4. Of Mice and Men: The History of Embryonic Stem Cells

5. Origins and Types of Stem Cells: What’s in a Name?

6. Cloning: History and Current Applications

7. Regenerative Medicine: Clinical Applications of Stem Cells

8. Stem Cells in Veterinary Medicine

9. Cardiomyocytes from Stem Cells: What can we do with them?

10. Adult Stem Cells: Generation of Self-Organizing Mini-Organs in a Dish

11. Stem Cell Tourism

12. Cancer Stem Cells: Where do they come from and where are they going?

13. Human Stem Cells for Organ-on-Chips: Clinical Trials without Patients

14. Stem Cells for Discovery of Effective and Safe New Drugs

15. Patients, Opportunities, and Challenges: Legal and Intellectual Property Issues associated with Stem Cells

16. Stem Cell Perspectives: A Vision of the Future

Christine Mummery is a Professor of Developmental Biology at Leiden University Medical Centre in the Netherlands and head of the Department of Anatomy and Embryology. Her research concerns heart development and the differentiation of pluripotent human stem cells into the cardiac and vascular lineages and using these cells as disease models, for safety pharmacology, drug discovery and future cardiac repair. Immediate interests are on developing biophysical techniques for characterization and functional analysis of cardiovascular cells from hPSC. She was recently awarded a multimillion grant for this purpose and is awardee of a prestigious European Research Council Advanced Grant. A member of the Royal Netherlands Academy of Science, and former board member of the International Society of Stem Cell research and the Netherlands Medical Research Council, she’s editor in chief of the ISSCR journal Stem Cell Reports and is also on the editorial boards of Cell Stem Cell, Cardiovascular Research and Stem Cells.