okvet [The Common Marmoset in Captivity and Biomedical Research, 1st Edition

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Editors: Robert Marini Lynn Wachtman Suzette Tardif Keith Mansfield James Fox

ISBN: 9780128118290

Imprint: Academic Press

Published Date: November 2018

Page Count: 570

Description

The Common Marmoset in Captivity and Biomedical Research is the first text dedicated exclusively to this species,filling an urgent need for an encyclopedic compilation of the existing information. Sponsored by the American
College of Laboratory Animal Medicine as part of its authoritative Blue Book series, the book covers the biology,management, diseases, and clinical and research applications of this important species. The common marmoset
(Callithrix jacchus) has come of age in the scientific community as a behaviorally complex, cognitively advanced,small, prolific, and easily maintained nonhuman primate with many of the advantages of larger animals, such as
macaques, but without the attendant physical and zoonotic risks.

Marmosets are currently being used in diverse areas of inquiry, including vision and auditory research, infectious disease, cognitive neuroscience, behavior, reproductive biology, toxicology and drug development, and aging. The
marmoset genome has been sequenced and there is currently an intensive effort to apply gene editing technologies to the species. The creation of transgenic marmosets will provide researchers with a small nonhuman primate
model to study a number of poorly understood disorders, like autism.

Key Features

Presents a complete view of the marmoset, covering their biology and management, diseases and clinical applications, and research applications

Includes contributions from renowned and international authors and editors

Provides the first authoritative and comprehensive treatment of marmosets in biomedical research as part of the ACLAM Series

Readership

Vivarium professionals maintaining marmoset colonies, veterinarians responsible for their care and well-being, zoologists and ethologists studying the species, and investigators using them to gain critical insights into human physiology and disease

Table of Contents

Section I: BIOLOGY AND MANAGEMENT
1. Taxonomy and Natural History
2. The Anatomy of the Common Marmoset
3. Neuroanatomy of the Marmoset
4. Marmoset Nutrition and Dietary Husbandry
5. Husbandry and Housing of Common Marmosets
6. Normal Clinical and Biological Parameters of the Common Marmoset (Callithrix jacchus)
7. Behavior and Behavioral Management
8. Reproduction, Growth, and Development
9. Regulatory Considerations

Section II: DISEASES AND CLINICAL APPLICATIONS
10. Physical Examination, Diagnosis, and Common Clinical Procedures
11. Anesthesia and Common Surgical Procedures
12. Diseases of the Urogenital System
13. Diseases of the Gastrointestinal System
14. Bone, Muscle, and Skeletal Disease
15. Viral Diseases of Common Marmosets
16. Bacterial Diseases
17. Parasitic Diseases
18. Neoplastic Diseases

Section III: RESEARCH AND APPLICATIONS
19. The Genome of the Common Marmoset
20. Creating Genetically Modified Marmosets
21. Marmosets in Aging Research
22. The Marmoset Monkey as a Model for Visual Neuroscience
23. Marmosets in Neurologic Disease Research: Parkinson’s Disease
24. Experimental Autoimmune Encephalomyelitis in the Marmoset as a Translational Model for Multiple Sclerosis
25. Marmosets in Auditory Research
26. The Marmoset as a Model in Behavioral Neuroscience and Psychiatric Research
27. The Use of the Marmoset in Toxicity Testing and Nonclinical Safety Assessment Studies
28. Experimental Infections of the Common Marmoset (Callithrix jacchus)
29. Insights Gained from Marmoset Endocrine Research

About the Editors

Robert Marini

Robert P. Marini, DVM, DACLAM, Assistant Director, is a member of MIT’s Division of Comparative Medicine’s clinical staff and is Chief of the Division’s clinical surgical facilities. Dr. Marini is responsible for coordinating and supervising all major survival surgery in non-rodent mammalian species.

Lynn Wachtman

Harvard Medical School, Boston MA USA

Suzette Tardif

Suzette D. Tardif, Ph.D., is the Associate Director of Research at the Southwest National Primate Research Center. She is an adjunct faculty of The Barshop Institute. The Tardif laboratory's activities center on the development of the marmoset monkey as a disease model. Dr. Tardiff is a past-President of the American Society of Primatologists.

Keith Mansfield

Keith Mansfield is Associate Director for Resource and Collaborative Affairs and Chair, Division of Primate Resources, New England National Primate Research Center, Harvard Medical School, Harvard University, Southborough, US. His research focuses on primarily on the recognition of spontaneously occurring infectious diseases of nonhuman primates and their development into novel animal models to investigate disease pathogenesis.

James Fox

James G. Fox, DVM, MS, DACLAM, is a Professor and Director of the Division of Comparative Medicine and a Professor in the Division of Biological Engineering at the Massachusetts Institute of Technology. He is also an Adjunct Professor at Tufts University School of Veterinary Medicine and the University of Pennsylvania, School of Veterinary Medicine. He is a Diplomate and a past president of the American College of Laboratory Animal Medicine, past president of the Massachusetts Society of Medical Research, past chairman of AAALAC Council, and past chairman of the NCCR/NIH Comparative Medicine Study Section. He also is an elected fellow of the Infectious Disease Society of America. Professor Fox is the author of over 490 articles, 80 chapters, 3 patents and has edited and authored 13 texts in the field of in vivo model development and comparative medicine.