Description

This cutting-edge resource includes up-to-date information on zebrafish physiology and the tools used to study it, not only as a model species for studies of other vertebrates but with application for studies of human disease and aquatic toxicology. The utility of zebrafish for physiological research is based on several key features including i) a ";fully"; sequenced genome, ii) rapid (~3 month) generation times), iii) their capacity to produce large numbers of externally fertilized eggs, iv) optical transparency of embryos and larvae, and v) the applicability of reverse and forward genetics to assess gene function. Gene knockdown in embryos and the production of transgenic strains are now standard techniques being used to assess physiology. This book will be of keen interest not only to the typical readers of Fish Physiology but also to biomedical researchers, toxicologists and developmental biologists.

Contents

Genetic Tools; The Nervous System; Vision; The Endocrine System; The Cardiovascular system; Respiration; Ionic and Acid-Base Regulation; The Kidney; The Zebrafish as a Model for Human Disease; The Zebrafish as a Model for Environmental Toxicology

Author Information

Steve F. Perry, Department of Biology, University of Ottawa, Ontario, Canada; Marc Ekker, Center for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ontario, Canada; Anthony P. Farrell, Department of Zoology, University of British Columbia, Vancouver, Canada and Colin J. Brauner, Department of Zoology, University of British Columbia, Vancouver, Canada