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Basic Immunology, 7th Edition- Functions And Disorders Of The Immune System (Á¾ÀÌÃ¥+eBook)
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Basic Immunology, 7th Edition- Functions And Disorders Of The Immune System



ISBN Number          9780443105197

Main Author            By Abul Abbas, MBBS, Andrew Lichtman, MD, PhD and Shiv Pillai, MBBS, PhD

Copyright Year        2024

Trim                    235 x 191 (7 1/2 x 9 1/4)

Imprint                  Elsevier

Page Count            352

Publication Date       15 May 2023



Description

Meticulously reviewed and updated for today's medical students, Basic Immunology, 7th Edition, is a concise text expertly written by the same distinguished author team as the best-selling, comprehensive text, Cellular and Molecular Immunology. This focused, easy-to-understand volume has been fully revised to include recent important advances in our understanding and knowledge of the immune system. A student favorite through six outstanding editions, this new edition uses full-color illustrations and clinical images, useful tables, and practical features such as Summary Point boxes, end-of-chapter review questions, glossary terms, and clinical cases—all designed to help you master this complex topic in the most efficient, effective manner possible.



Key Features


Emphasizes clinical aspects of immunology, including disease pathogenesis, the development of novel therapies based on basic science, and an appendix of clinical cases for real-world application. 


Contains new and expanded content on pandemics, COVID-19, and herd immunity; resistance and susceptibility to COVID-19; RNA vaccines and hybrid viral vaccines; tumor immunotherapy; innate immune responses to viruses; mechanisms of immunologic tolerance; and immunotherapy for autoimmune, allergic, and other inflammatory diseases, and cancer. 


Provides unrivalled instruction from an expert author team, all of whom are experienced teachers, course directors, and lecturers. 


Features a highly readable writing style and practical organization, now with fully revised content and updated images to cover new information and improve reader understanding of complex concepts. 


Provides additional online features such as answers to in-book chapter review questions and self-assessment questions. 


Presents information in a format and style that maximizes usefulness to students and teachers of medicine, allied health fields, and biology. 


Contains numerous features designed to help students understand key immunologic concepts: high-quality illustrations, practical tables, chapter outlines, bolded key points, and focus questions in every chapter for self-assessment and review. 


An eBook version is included with purchase. The eBook allows you to access all the text and figures, with the ability to search, customize your content, make notes and highlights, and have content read aloud. 


  


Table of Contents

Instructions for online access

Cover image

Title page

Table of Contents

Copyright

Dedication

Preface

1. Introduction to the Immune System: Nomenclature, General Properties, and Components

Infections and Immunity

Immunologic Disorders

Stages of Host Defense: Innate and Adaptive Immunity

Properties of Adaptive Immune Responses

Cells of the Adaptive Immune System

Tissues of the Immune System

Summary

2. Unlabeled image.Innate Immunity: The Early Defense Against Infections

General Features and Specificity of Innate Immune Responses

Cellular Receptors for Microbes and Damaged Cells

Components of Innate Immunity

Innate Immune Reactions

Role of Innate Immunity in Stimulating Adaptive Immune Responses

Summary

3. Antigen Presentation to T Lymphocytes and the Functions of Major Histocompatibility Complex Molecules: What T Lymphocytes See

Antigens Recognized by T Lymphocytes

Capture of Protein Antigens by Antigen-Presenting Cells

Structure and Function of Major Histocompatibility Complex Molecules

Processing and Presentation of Protein Antigens

Functions of Antigen-Presenting Cells in Addition to Antigen Display

Antigen Recognition by Other T Lymphocytes

Summary

4. Antigen Recognition in the Adaptive Immune System: Structure of Lymphocyte Antigen Receptors and Development of Immune Repertoires

Antigen Receptors of Lymphocytes

Development of B and T Lymphocytes

Summary

5. T Cell–Mediated Immunity: Activation of T Lymphocytes

Steps in T Cell Responses

Antigen Recognition and Costimulation

Biochemical Pathways of T Cell Activation

Functional Responses of T Lymphocytes to Antigen and Costimulation

Regulation of T Cell Responses by Inhibitory Receptors (Coinhibitors)

Migration of T Lymphocytes in Cell-Mediated Immune Reactions

Decline of the Immune Response

Summary

6. Effector Mechanisms of T Cell–Mediated Immunity: Functions of T Cells in Host Defense

Types of T Cell–Mediated Immune Reactions

Development and Functions of CD4+ Effector T Lymphocytes

Differentiation and Functions of CD8+ Cytotoxic T Lymphocytes

Resistance of Pathogenic Microbes to Cell-Mediated Immunity

Summary

7. Humoral Immune Responses: Activation of B Lymphocytes and Production of Antibodies

Phases and Types of Humoral Immune Responses

Stimulation of B Lymphocytes by Antigen

Functions of Helper T Lymphocytes in Humoral Immune Responses

Antibody Responses to T-Independent Antigens

Regulation of Humoral Immune Responses

Summary

8. Effector Mechanisms of Humoral Immunity: Elimination of Extracellular Microbes and Toxins

Properties of Antibodies That Determine Effector Functions

Neutralization of Microbes and Microbial Toxins

Opsonization and Phagocytosis

Antibody-Dependent Cellular Cytotoxicity

Immunoglobulin E– and Mast Cell–Mediated Reactions

The Complement System

Functions of Antibodies at Special Anatomic Sites

Evasion of Humoral Immunity by Microbes

Vaccination

Summary

9. Immunologic Tolerance and Autoimmunity: Self–Nonself Discrimination in the Immune System and Its Failure

Immunologic Tolerance: General Priniciples and Significance

Central T Lymphocyte Tolerance

Peripheral T Lymphocyte Tolerance

B Lymphocyte Tolerance

Tolerance to Commensal Microbes and Fetal Antigens

Autoimmunity

Summary

10. Tumor and Transplantation Immunology: Immune Responses to Cancer Cells and Normal Foreign Cells

Immune Responses Against Tumors

Immune Responses Against Transplants

Summary

11. Hypersensitivity: Disorders Caused by Immune Responses

Types of Hypersensitivity Reactions

Immediate Hypersensitivity

Diseases Caused by Antibodies Specific for Cell and Tissue Antigens

Diseases Caused by Antigen-Antibody Complexes

Diseases Caused by T Lymphocytes

Summary

12. Immunodeficiency Diseases: Disorders Caused by Defective Immunity

Primary (Congenital) Immunodeficiencies

Acquired (Secondary) Immunodeficiencies

Acquired Immunodeficiency Syndrome (AIDS)

Summary

Appendix I. Principal Features of Selected CD Molecules

Appendix II. Cytokines

Appendix III. Clinical Cases

Answers to Review Questions

Index



Author Information

By Abul Abbas, MBBS, Distinguished Professor and Chair, Department of Pathology, University of California San Francisco, San Francisco, California ; Andrew Lichtman, MD, PhD, Associate Professor of Pathology, Harvard Medical School and Brigham and Women's Hospital, Boston, MA and Shiv Pillai, MBBS, PhD, Massachusetts General Hospital Cancer Center, Boston, MA, USA






 
 
 
 
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