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기초 생명의과학 > Biochemistry > Medical Biochemistry, 2e - 신간POD상품

 
Medical Biochemistry, 2e - 신간POD상품
상품명 : Medical Biochemistry, 2e - 신간POD상품
제조회사 : Academic Press
원산지 : USA
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Medical Biochemistry, 2e - 신간POD상품



신간POD(Printed On Demand/주문형서적) 상품 안내


이 도서는 신간POD상품입니다.


신간POD: 신간도서이나 출판사의 물류비 절감을 위해 주문시마다 제작하는 도서



Authors: Antonio Blanco, Gustavo Blanco
Pages: 908
Published: March 23, 2022
Imprint: Academic Press
ISBN: 9780323915991



Description


This second edition of Medical Biochemistry is supported by more than 45 years of teaching experience, providing coverage of basic biochemical topics, including the structural, physical, and chemical properties of water, carbohydrates, lipids, proteins, and nucleic acids. In addition, the general aspects of thermodynamics, enzymes, bioenergetics, and metabolism are presented in straightforward and easy-to-comprehend language. This book ties these concepts into more complex aspects of biochemistry using a systems approach, dedicating chapters to the integral study of biological phenomena, including cell membrane structure and function, gene expression and regulation, protein synthesis and post-translational modifications, metabolism in specific organs and tissues, autophagy, cell receptors, signal transduction pathways, biochemical bases of endocrinology, immunity, vitamins and minerals, and hemostasis. The field of biochemistry is continuing to grow at a fast pace. This edition has been revised and expanded with all-new sections on the cell plasma membrane, the human microbiome, autophagy, noncoding, small and long RNAs, epigenetics, genetic diseases, virology and vaccines, cell signaling, and different modes of programmed cell death. The book has also been updated with full-color figures, new tables, chapter summaries, and further medical examples to improve learning and better illustrate the concepts described and their clinical significance.



Key Features


  • Integrates basic biochemistry principles with molecular biology and molecular physiology
  • Illustrates basic biochemical concepts through medical and physiological examples
  • Utilizes a systems approach to understanding biological phenomena
  • Fully updated for recent studies and expanded to include clinically relevant examples and succinct chapter summaries


  • Readership


    Researchers and clinicians in biochemistry, molecular biology, and molecular medicine; medical faculty, and postdocs, medical students



    Table of Contents


    Copyright
    Dedication
    Preface
    Cover
    Introduction
    Chapter 1: Chemical composition of living beings
    Abstract
    Biogenic elements
    Biological compounds
    Summary
    Further reading
    Chapter 2: Water
    Abstract
    The water molecule is polar
    Hydrogen bond
    Water as solvent
    Water as an electrolyte
    Equilibrium constant
    Equilibrium of water ionization
    Acids and bases
    The strength of acids and bases
    pH
    Buffers
    Titration curve of acids and bases
    Appendix
    Summary
    Further reading
    Chapter 3: Proteins
    Abstract
    Proteins are macromolecules formed by amino acids
    Amino acids
    Peptides
    Proteins
    Collagen
    Keratins
    Hemoglobin
    Heme
    Globin
    Hemoglobin derivatives
    Abnormal hemoglobins
    Blood plasma proteins
    Main plasma proteins
    Muscle proteins
    Muscle contraction
    Proteomics
    Summary
    Further reading
    Chapter 4: Carbohydrates
    Abstract
    Monosaccharides
    Disaccharides
    Polysaccharides
    Summary
    Further reading
    Chapter 5: Lipids
    Abstract
    Classification
    Fatty acids
    Essential fatty acids
    Simple lipids
    Complex lipids
    Substances associated with lipids
    Summary
    Further reading
    Chapter 6: Nucleic acids
    Abstract
    Nucleotides
    Nucleic acids
    Virus
    Free nucleotides
    Summary
    Further reading
    Chapter 7: Elements of thermodynamics and biochemical kinetics
    Abstract
    Thermodynamics
    The cell as an open system
    Chemical kinetics
    Summary
    Further reading
    Chapter 8: Enzymes
    Abstract
    Enzymes are biological catalysts
    Nomenclature and classification of enzymes
    Chemical nature of enzymes
    Metalloenzymes
    Enzymatic catalysis
    Active site
    Zymogens
    Genetic alterations that affect enzyme function
    Enzyme distribution within the cell
    Multienzyme systems
    Determination of enzyme activity
    Factors that modify enzyme activity
    Enzyme inhibitors
    Regulation of enzyme activity
    Constitutive and inducible enzymes
    Enzymatic processes in cascade
    Isozymes
    Determination of enzymes in the clinical laboratory
    Summary
    Further reading
    Chapter 9: Biological oxidations: Bioenergetics
    Abstract
    The energy-rich intermediate ATP
    Oxidation-reduction
    Biological oxidations
    Respiratory chain
    Oxidative phosphorylation
    Phosphorylation at substrate level
    Other electron transport systems
    Summary
    Further reading
    Chapter 10: Antioxidants
    Abstract
    Reactive species
    Summary
    Further reading
    Chapter 11: Membranes
    Abstract
    Structure
    Transport across membranes
    Passive transport or facilitated diffusion
    Active transport
    Summary
    Further reading
    Chapter 12: Digestion—Absorption
    Abstract
    Saliva
    Gastric secretion
    Pancreatic juice
    Intestinal mucosa
    Bile
    Summary of the digestive process
    Absorption
    Gastrointestinal microbiome
    Summary
    Further reading
    Chapter 13: Metabolism
    Abstract
    Metabolic pathways
    Metabolic studies
    Regulation of metabolism
    Summary
    Further reading
    Chapter 14: Carbohydrate metabolism
    Abstract
    Glucose uptake into cells
    Glucose phosphorylation
    Metabolic pathways for glucose
    Metabolism of other hexoses
    Biosynthesis of oligosaccharides in glycoproteins
    Summary
    Further reading
    Chapter 15: Lipid metabolism
    Abstract
    Plasma lipoprotein metabolism
    Fat metabolism
    Fatty acid biosynthesis
    Eicosanoid biosynthesis
    Triacylglycerol biosynthesis
    Phospholipid biosynthesis
    Congenital disorders of complex lipid catabolism
    Cholesterol metabolism
    Cholesterol biosynthesis
    Alterations of plasma lipids
    Summary
    Further reading
    Chapter 16: Amino acid metabolism
    Abstract
    Essential AA
    Amino acid catabolism
    Metabolic pathways of ammonia
    Other general mechanisms of amino acid metabolism
    Metabolic pathways of AA
    Summary
    Further reading
    Chapter 17: Heme metabolism
    Abstract
    Heme biosynthesis
    Catabolism of heme
    Summary
    Further reading
    Chapter 18: Purine and pyrimidine metabolism
    Abstract
    Purine biosynthesis
    Purine salvage pathway
    Purine catabolism
    Uric acid
    Gout
    Pyrimidine biosynthesis
    Pyrimidine catabolism
    Di- and triphosphate nucleoside biosynthesis
    Deoxyribonucleotide biosynthesis
    Pharmacological approaches to purine and pyrimidine metabolism
    Summary
    Further reading
    Chapter 19: Integration and regulation of metabolism
    Abstract
    Interconversion of carbohydrates, lipids, and amino acids
    Metabolic regulation
    Summary
    Further reading
    Chapter 20: Metabolism in some tissues
    Abstract
    Liver metabolism
    Skeletal muscle metabolism
    Heart metabolism
    Adipose tissue metabolism
    Nervous tissue metabolism
    Summary
    Further reading
    Chapter 21: The genetic information (I)
    Abstract
    DNA replication
    Transcription
    Molecular biology
    Summary
    Further reading
    Chapter 22: The genetic information (II)
    Abstract
    Protein biosynthesis
    Mechanism of protein synthesis
    Genetic mutations
    Oncogenes
    Epigenetics
    Summary
    Further reading
    Chapter 23: Regulation of gene expression
    Abstract
    Gene regulation in eukaryotes
    Gene regulation by noncoding RNAs
    Small noncoding RNAs
    Long noncoding RNAs
    Riboswitches
    Summary
    Further reading
    Chapter 24: Posttranslational protein modifications
    Abstract
    Protein folding
    Pathologies caused by misfolded proteins
    Posttranslational protein modifications
    Summary
    Further reading
    Chapter 25: Biochemical basis of endocrinology (I) receptors and signal transduction
    Abstract
    Receptors
    Signal transduction systems
    Summary
    Further reading
    Chapter 26: Biochemical bases of endocrinology (II) hormones and other chemical intermediates
    Abstract
    Hormones
    Endocrine glands and their hormones
    Placental hormones
    Thyroid hormones
    Adrenal gland hormones
    Pancreatic hormones
    Gonadal hormones
    Parathyroid gland hormones
    Kidney hormones
    Heart hormones
    Gastrointestinal hormones
    Pineal gland hormone
    Eicosanoids
    Growth factors
    Nervous system chemical intermediaries (Neurotransmitters)
    Summary
    Further reading
    Chapter 27: Vitamins
    Abstract
    Fat-soluble vitamins
    Water-soluble vitamins
    Summary
    Further reading
    Chapter 28: Water and acid-base balance
    Abstract
    Water distribution in the body
    Water balance
    Ionic composition of body fluids
    Alterations of the water balance
    H+ concentration in body fluids
    Regulation of H+ concentration
    Carbon dioxide transport
    Regulatory systems
    Respiratory regulation
    Renal regulation
    Regulation of intracellular pH
    Acid-base balance disorders
    H+ excretion regulation
    Laboratory studies in acid-base disorders
    Summary
    Further reading
    Chapter 29: Essential minerals
    Abstract
    Macrominerals
    Trace elements
    Summary
    Further reading
    Chapter 30: Molecular basis of immunity
    Abstract
    Immune system
    Innate system
    Adaptive system
    Genetic diversity of immunoglobulins
    Complement
    Cellular immunity
    Cytokines
    Vaccines
    Summary
    Further reading
    Chapter 31: Hemostasis
    Abstract
    Blood coagulation
    Coagulation disorders
    Summary
    Further reading
    Chapter 32: Cell death
    Abstract
    Apoptosis
    Summary
    Further reading
    Index



    About the Authors


    Antonio Blanco

    Dr. Antonio Blanco is an M.D. and Ph.D. at the National University of Cordoba, Argentina. He was Research Associate at The Johns Hopkins School of Medicine at Baltimore (US) for 4 years. He has been the Chairman of the Department of Biochemistry of the National University of Cordoba for 31 years and is currently Emeritus Professor of the National University of Cordoba, Argentina. He is also a member of several academic societies, including the National Academy of Sciences, and the National Academy of Physical and Natural Sciences of Argentina.

    Affiliations and Expertise

    Emeritus Professor, National University of Cordoba, Cordoba, Argentina

    Gustavo Blanco

    Dr. Gustavo Blanco is an M.D. and Ph.D. from the University of Cordoba, Argentina and currently a Professor at Kansas University Medical Center. Dr. Blanco’s research focuses on renal biology and reproductive biology, as well as regulation and function of Na,K-ATPase isozymes. He has published widely in such peer reviewed journals as the Journal of Medicinal Chemistry, Steroids, Experimental Cell Research, Molecules, Frontiers in Physiology, and the American Journal of Physiology.

    Affiliations and Expertise

    Professor and Kathleen M. Osborn Chair, Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS United States

     
     
     
     
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