Medicinal Plants as Anti-infectives: Current Knowledge and New Perspectives, 1st Edition

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Editor: Francois Chassagne
ISBN: 9780323909990
Published: March 2022
Imprint: Academic Press
Pages: 586

Description

Medicinal Plants as Anti-infectives: Current Knowledge and New Perspectives provides comprehensive and updated data on medicinal plants and plant-derived compounds used as antimicrobials in a range of locations (such as the Balkans, Colombia, India, Lebanon, Mali, Pakistan, Southeast Asia, South Africa, and West Africa). It also provides an overview on the most recent innovations and regulations in the field of drug discovery from ethnobotanical sources. This book will help readers to better appreciate the role of plants and phytomedicines as anti-infectives, to better assess the health benefits of plant-derived products, to help implement new methodologies for studying medicinal plants, and to guide future researchers in the field. Medicinal Plants as Anti-infectives: Current Knowledge and New Perspectives is a valuable resource for students, academic scientists, and researchers from the fields of ethnobotany, pharmacy, medicinal chemistry, and microbiology, as well as for professionals working in national or international health agencies, or in pharmaceutical industries.

Key Features

Readership

Scientists and students in the fields of phytomedicine, pharmacognosy, ethnobotany, ethnopharmacology, and phytochemistry. Pharmaceutical companies and national/international health agencies

Table of Contents

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface

Part I: Medicinal plants as anti-infectives: an appraisal of current knowledge worldwide
Chapter 1. A review of medicinal plants used as antimicrobials in Colombia
Abstract
Introduction
Materials and methods
Plants traditionally used in Colombia as antimicrobials
Biological evaluation as antimicrobials of plant extracts in Colombia
Antibacterial evaluation of 25 native plants of the Colombian Caribbean region against strains of Escherichia coli, Klebsiella pneumonia, and Pseudomonas aeruginosa resistant to carbapenems and Staphylococcus aureus resistant to methicillin (Colciencias, Project code: 110777757752)
Conclusions
References

Chapter 2. Plants used in Lebanon and the Middle East as Antimicrobials
Abstract
Introduction: overview on medicinal plants and their traditional uses as antimicrobials in Lebanon
Lebanese plants with antimicrobial activity
Conclusion
Acknowledgment
References

Chapter 3. Medicinal plants in the Balkans with antimicrobial properties
Abstract
Introduction
Medicinal plants with antimicrobial properties
Conclusions
References

Chapter 4. Medicinal plants used in South Africa as antibacterial agents for wound healing
Abstract
Introduction
Pathophysiology of wound healing
Wound infection
Currently available treatments and products
Bacteria associated with infections of dermal wounds
South African medicinal plant species with activity against wound-associated bacteria
Compounds present in plants traditionally used for wound healing in South Africa
Discussion
Conclusion
Index
Glossary
References

Chapter 5. The use of South African medicinal plants in the pursuit to treat gonorrhea and other sexually transmitted diseases
Abstract
Introduction
Background on gonorrhea
Status of available treatments for gonorrhea
Selected South African plants used in traditional medicine for the treatment of sexually transmitted diseases and their bioactivity
Conclusion
References

Chapter 6. Antibacterial activity of some selected medicinal plants of Pakistan
Abstract
Introduction
Antibacterial properties of different medicinal plants from Pakistan
Conclusion
References

Chapter 7. Medicinal plants used as antidiarrheal agents in the lower Mekong basin
Abstract
Introduction
Traditional medicine for diarrheal diseases in the Mekong Basin
Models assessing the effect of plants on the signs and symptoms of diarrhea
Models assessing the antimotility and antisecretory activities
Models assessing the antiinfective properties
Medicinal plants used for diarrhea in the lower Mekong basin
Discussion of some selected plant species
Conclusion
References

Chapter 8. Medicinal plants from West Africa used as antimalarial agents: an overview
Abstract
Introduction
Traditional use of medicinal plants in West Africa
Plant extracts and plant compounds validated by in vitro and/or in vivo approach
The case of Artemisia in West Africa
Conclusion
References

Part II: Medicinal plants as anti-infectives: recent innovations and regulations
Chapter 9. Mycobacterial quorum quenching and biofilm inhibition potential of medicinal plants
Abstract
Introduction
Significance of quorum quenching research
Current state of quorum quenching research
Quorum sensing versus quorum quenching
Biofilms
Biofilms and Mycobacterium tuberculosis
Virulence factors
Virulence factors and Mycobacterium tuberculosis
Medicinal plants as quorum quenching agents
Medicinal plants and mycobacterial quorum quenching
Phytochemicals used in bacterial quorum quenching
Conclusion
References

Chapter 10. Untargeted metabolomics for the study of antiinfective plants
Abstract
Introduction
Plants as sources of antiinfective agents
Bioassay-guided fractionation
Metabolomics
Methods of detection
Data analysis
Biochemometrics
Metabolomics-driven antiinfective discovery from plants
Challenges and future directions
Metabolome coverage
Annotation/identification
Synergy
Conclusions
References

Chapter 11. Value chains and DNA barcoding for the identification of antiinfective medicinal plants
Abstract
Introduction
Materials and methods
Results and discussion
Future perspectives
References

Chapter 12. Fungal endophytes: a source of antibacterial and antiparasitic compounds
Abstract
Introduction
Antimicrobial compounds from endophytic fungi
Discussion and conclusion
References

Chapter 13. Antiviral potential of medicinal plants: a case study with guava tree against dengue virus using a metabolomic approach
Abstract
Introduction
Case study: metabolomics reveal antidengue compounds isolated from Psidium guajava
Acknowledgments
References

Chapter 14. How history can help present research of new antimicrobial strategies: the case of cutaneous infections’ remedies containing metals from the Middle Age Arabic pharmacopeia
Abstract
Introduction
Brief history of Arabic medicine
Cutaneous infections and medications
Conclusion
References

Chapter 15. Improved traditional medicine for infectious disorders in Mali
Abstract
Introduction
General information on improved traditional medicines
Categories of improved traditional medicines
Marketing authorization files for ITMs in Mali
Historical development of ITMs in Mali
ITMs in the management of infectious diseases
Conclusion and perspectives
Index of ITMs
References

Chapter 16. Selecting the most promising local treatments: retrospective treatment-outcome surveys and reverse pharmacology
Abstract
Introduction
Clinical efficacy
Reverse pharmacology approach
New and promising approaches for the laboratory stage in a reverse pharmacology approach
Conclusion and perspectives
Acknowledgments
References

Chapter 17. Nagoya Protocol and access to genetic resources
Abstract
Introduction
History and evolution of concepts
Discussion
New trends and evolutions
Conclusion
Acknowledgments
References
Index

About the Editor

Francois Chassagne
François Chassagne is a pharmacist and researcher at the IRD (French National Research Institute for Sustainable Development) in the UMR 152 PharmaDev research unit based in Toulouse, France. He graduated from the School of Pharmacy at Paris Descartes University in France, and he obtained his Ph.D. degree in Pharmacology at the Paul Sabatier University in Toulouse, France. He was a postdoctoral fellow specializing in the study of anti-infective medicinal plants at Emory University in Atlanta, GA in the United States. He is currently working in the field of ethnopharmacology, developing ethnobotanical and pharmacological tools to validate the use of traditional remedies.